SynthesisClinical oral investigations2012
The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Association between overweight/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review.GeroScience · 2023Pooled it
- Oral Health Promotion under the 8020 Campaign in Japan-A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- The Combined Impact of Edentulism and Hypertension on All-Cause Mortality: A 7-Year Prospective Cohort Study.International dental journal · 2026Article
- Could periodontitis be associated with overall and cancer-specific mortality risk; a 35-year Swedish cohort study.Acta odontologica Scandinavica · 2025Article
- Association between the number of teeth and all-cause mortality rate in the MASHAD Cohort Study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Global and Regional Patterns in Edentulism (1990-2021) With Predictions to 2040.International dental journal · 2025Article
- Oral Health and Older Adults: A Narrative Review.Dentistry journal · 2024Review
- Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity.Frontiers in aging · 2024Review
- Quantitative Assessment of Systematic Bias: A Guide for Researchers.Journal of dental research · 2023Review
- Integrating Oral Health into Primary Care: Perspectives for Older Adults.Journal of dental research · 2023Article
- Frailty mediated the association between tooth loss and mortality in the oldest old individuals: a cohort study.Frontiers in public health · 2023Article
- Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study.Metabolites · 2022Article
- Impact of number of functional teeth on independence of Japanese older adults.Geriatrics & gerontology international · 2022Article
- Tooth Loss, Cognitive Impairment and Fall Risk: A Cross-Sectional Study of Older Adults in Rural Thailand.International journal of environmental research and public health · 2022Article
- Reduced masticatory performance and not using dentures are associated with hypertension in older adults with tooth loss: the Shimane CoHRE study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Tooth retention, health, and quality of life in older adults: a scoping review.BMC oral health · 2022Article
- Article
- Oral Health among Elderly, Impact on Life Quality, Access of Elderly Patients to Oral Health Services and Methods to Improve Oral Health: A Narrative Review.Journal of personalized medicine · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We systematically reviewed whether the number of teeth is related to all-cause or circulatory mortality and whether replaced teeth are protective against all-cause or circulatory mortality. The search was based on the PubMed database. All cohort studies published in peer-reviewed journals were selected. Studies on periodontal disease and mortality were excluded if they did not provide information on the number of teeth. Risk estimates from studies with appropriate exposure definition, confounder adjustment and sample size were included in a meta-analysis. Three high-quality studies found a relationship between the number of teeth and circulatory mortality, whereas a moderate study did not. Two out of four moderate- to high-quality studies reported a relationship between the number of teeth and all-cause mortality. No study has investigated whether replaced teeth are protective against mortality. Therefore, denture use was taken as proxy. The methodological quality of studies on denture use and mortality was generally low to moderate. The findings of two moderate studies indicated an effect of prosthodontic replacements on all-cause mortality, which was supported in bias analysis. It is open whether competing risks of cause-specific death other than circulatory mortality reduce an effect of the number of teeth on all-cause mortality. An effect of denture use on circulatory mortality remains to be established, as well as whether the number of replaced teeth affects mortality. Specifying the role of potential pathways by which tooth loss-related mortality is mediated will possibly increase the value of dental treatment for general health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.