ArticleNature communications2011
Functionalized arrays of Raman-enhancing nanoparticles for capture and culture-free analysis of bacteria in human blood.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent advances in surface enhanced Raman spectroscopy for bacterial pathogen identifications.Journal of advanced research · 2023Pooled it
- SERS-Based Universal AST: Rapid Treatment Guidance for Blood-Culture Bacteria before Species Identification.Analytical chemistry · 2026Article
- An Interpretable SERS-AI Platform for Rapid and Quantitative Diagnosis of Polymicrobial UTIs: Powered by Positively Charged Plasmonic Nanoparticles and Attention-Based Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Machine Learning-Assisted SERS Platform for Rapid and Quantitative Discrimination of Shiga Toxin-ProducingBiosensors · 2025Article
- Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer.Light, science & applications · 2024Article
- 2D Material-Based Surface-Enhanced Raman Spectroscopy Platforms (Either Alone or in Nanocomposite Form)-From a Chemical Enhancement Perspective.ACS omega · 2024Article
- Review
- Multifunctional Carbon Nanodots for Antibacterial Enhancement, pH Change, and Poisonous Tin(IV) Specifical Detection.ACS omega · 2023Article
- Machine learning-augmented surface-enhanced spectroscopy toward next-generation molecular diagnostics.Nanoscale advances · 2023Review
- Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review.Journal of nanobiotechnology · 2022Review
- Recent Advances in Nanotechnology for the Management ofBiosensors · 2022Review
- Review of Label-Free Monitoring of Bacteria: From Challenging Practical Applications to Basic Research Perspectives.Biosensors · 2022Review
- Rapid, Label-Free Prediction of Antibiotic Resistance inInternational journal of molecular sciences · 2022Article
- Rapid detection and identification of bacteria directly from whole blood with light scattering spectroscopy based biosensor.Sensors and actuators. B, Chemical · 2021Article
- Article
- Overview of Rapid Detection Methods forFoods (Basel, Switzerland) · 2021Review
- In situ food-borne pathogen sensors in a nanoconfined space by surface enhanced Raman scattering.Mikrochimica acta · 2021Review
- In Search of Spectroscopic Signatures of Periodontitis: A SERS-Based Magnetomicrofluidic Sensor for Detection ofACS sensors · 2021Article
- Rapid uropathogen identification using surface enhanced Raman spectroscopy active filters.Scientific reports · 2021Article
- Dual-signal lateral flow assay using vancomycin-modified nanotags for rapid and sensitive detection ofRSC advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting bacteria in clinical samples without using time-consuming culture processes would allow rapid diagnoses. Such a culture-free detection method requires the capture and analysis of bacteria from a body fluid, which are usually of complicated composition. Here we show that coating Ag-nanoparticle arrays with vancomycin (Van) can provide label-free analysis of bacteria via surface-enhanced Raman spectroscopy (SERS), leading to a ~1,000-fold increase in bacteria capture, without introducing significant spectral interference. Bacteria from human blood can be concentrated onto a microscopic Van-coated area while blood cells are excluded. Furthermore, a Van-coated substrate provides distinctly different SERS spectra of Van-susceptible and Van-resistant Enterococcus, indicating its potential use for drug-resistance tests. Our results represent a critical step towards the creation of SERS-based multifunctional biochips for rapid culture- and label-free detection and drug-resistant testing of microorganisms in clinical samples.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.