ArticlePlant molecular biology2012
Transient MPK6 activation in response to oxygen deprivation and reoxygenation is mediated by mitochondria and aids seedling survival in Arabidopsis.
Article in Plant molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Distinct processes contributing to post-submergence recovery determine leaf age-specific flood resilience in Arabidopsis.Plant physiology · 2026Article
- HNature · 2026Article
- MITOGEN-ACTIVATED PROTEIN KINASE9 fine-tunes hypoxia signaling by phosphorylating ERF-VII transcription factors in Arabidopsis.The New phytologist · 2026Article
- Biomarker signatures distinguish diabetic retinopathy and diabetic nephropathy.Diabetology international · 2025Article
- Bioinformatics Analysis Reveals PPR Genes Modulation by Ahyp-miR0005 Under Abiotic Stress Across Diverse Plant Species.Plants (Basel, Switzerland) · 2025Article
- Reactive oxygen species-post translational modifications-central carbon metabolism regulatory loop: coordination of redox homeostasis and carbon flux allocation in plants under abiotic stress.Frontiers in plant science · 2025Review
- Comparative Transcriptome Analyses Reveal the Mechanisms Underlying Waterlogging Tolerance in Barley.Plants (Basel, Switzerland) · 2024Article
- Primed to persevere: Hypoxia regulation from epigenome to protein accumulation in plants.Plant physiology · 2024Review
- Perception and processing of stress signals by plant mitochondria.The Plant journal : for cell and molecular biology · 2024Review
- Hypoxia represses pattern-triggered immune responses in Arabidopsis.Plant physiology · 2024Article
- New Insights into the Connections between Flooding/Hypoxia Response and Plant Defenses against Pathogens.Plants (Basel, Switzerland) · 2024Review
- Differential leaf flooding resilience in Arabidopsis thaliana is controlled by ethylene signaling-activated and age-dependent phosphorylation of ORESARA1.Plant communications · 2024Article
- Application of multiomics analysis to plant flooding response.Frontiers in plant science · 2024Review
- Multi-stress resilience in plants recovering from submergence.Plant biotechnology journal · 2023Review
- Complexity of Abiotic Stress Stimuli: Mimicking Hypoxic Conditions Experimentally on the Basis of Naturally Occurring Environments.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The colonization of land was a likely driving force for the evolution of mitochondrial retrograde signalling in plants.Journal of experimental botany · 2022Article
- The retrograde signaling regulator ANAC017 recruits the MKK9-MPK3/6, ethylene, and auxin signaling pathways to balance mitochondrial dysfunction with growth.The Plant cell · 2022Article
- Crosstalk between Melatonin and Reactive Oxygen Species in Plant Abiotic Stress Responses: An Update.International journal of molecular sciences · 2022Review
- GWAS on multiple traits identifies mitochondrial ACONITASE3 as important for acclimation to submergence stress.Plant physiology · 2022Article
- Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.The Plant cell · 2022Article
5 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Mitogen-activated protein kinases (MPKs) are regulated by diverse stresses with a reactive oxygen species (ROS) component. Here, we report the rapid and transient activation of MPK3, MPK4 and MPK6 upon oxygen deprivation as well as reoxygenation in seedlings of Arabidopsis thaliana. MPK activation peaked within 2 h of oxygen deprivation and again at a higher magnitude within 5 min of reoxygenation. MPK6 was the predominant kinase regulated by oxygen availability in both aerial and root tissue, except in mpk6 mutants, which displayed compensatory activation of MPK3. A universal consequence of oxygen deprivation in eukaryotes is inhibition of the terminal step of the mitochondrial electron transport chain (mETC). We demonstrate that treatment of seedlings with the mETC inhibitors antimycin A and potassium cyanide under normoxia promotes transient MPK6 and MPK3 activation. Confocal imaging of seedlings provided evidence that both oxygen deprivation and mETC inhibitors stimulate mitochondria-associated ROS production. We found that seedling survival of prolonged oxygen deprivation was improved in transgenics that ectopically overexpress MPK3, MPK4 and MPK6, but the induction of mRNAs associated with low oxygen acclimation responses were not markedly altered in MPK6 overexpression lines or mpk6 loss-of-function mutants. However, distinctions in MPK6 activation potential were correlated with other differences in mRNAs accumulation. Our findings suggest that oxygen deprivation and reoxygenation trigger mitochondrial ROS production to activate MPK signaling, which in turn regulate reversible processes that aid survival of transient oxygen deprivation.
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