ArticleEuropean journal of nutrition2012
Protective effects of olive oil phenolics and gallic acid on hydrogen peroxide-induced apoptosis.
Article in European journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Bioactivity and biomedical applications of pomegranate peel extract: a comprehensive review.Frontiers in pharmacology · 2025Review
- Characterization of Olive Oil Phenolic Extracts and Their Effects on the Aggregation of the Alzheimer's Amyloid-β Peptide and Tau.ACS omega · 2024Article
- Toward Enhanced Antioxidant and Protective Potential: Conjugation of Corn Cob Xylan with Gallic Acid as a Novel Approach.International journal of molecular sciences · 2024Article
- Morphological, immunohistochemical, and biochemical study on the ameliorative effect of gallic acid against bisphenol A-induced nephrotoxicity in male albino rats.Scientific reports · 2023Article
- A Concise Profile of Gallic Acid-From Its Natural Sources through Biological Properties and Chemical Methods of Determination.Molecules (Basel, Switzerland) · 2023Review
- Tyrosol and Olive Oil Ameliorate Sodium Arsenate-Induced Nephrotoxicity by Modulating of Oxidative Stress and Histological Changes in Mice.International journal of preventive medicine · 2023Article
- Antioxidant Activity of Fucoidan Modified with Gallic Acid Using the Redox Method.Marine drugs · 2022Article
- Antioxidant and Antimicrobial Potentials of Seed Oil fromOxidative medicine and cellular longevity · 2020Article
- Deltamethrin-Induced Hepatotoxicity and Virgin Olive Oil Consumption: An Experimental Study.Iranian journal of medical sciences · 2017Article
- Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis.Iranian journal of pathology · 2017Article
- In Vitro Investigation of Six Antioxidants for Pig Diets.Antioxidants (Basel, Switzerland) · 2016Article
- Virgin olive oil ameliorates deltamethrin-induced nephrotoxicity in mice: A biochemical and immunohistochemical assessment.Toxicology reports · 2016Article
- The anti-inflammatory and anti-apoptotic effects of gallic acid against mucosal inflammation- and erosions-induced by gastric ischemia-reperfusion in rats.Veterinary research forum : an international quarterly journal · 2015Article
- Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain.Iranian biomedical journal · 2015Article
- Antiapoptotic actions of methyl gallate on neonatal rat cardiac myocytes exposed to H2O2.Oxidative medicine and cellular longevity · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOlive oil contains several phenolic compounds possessing antioxidant activity. The aim of this study was to investigate the protective effects of olive oil phenolic extract (OOPE) and one of its constituents, gallic acid (GA) against H(2)O(2)-induced oxidative stress and apoptotic cell death in HeLa cells, a model for human epithelial cells.
methodsThe cells were pretreated with nontoxic doses of OOPE or GA for 4, 24 and 48 h, and the intracellular reactive oxygen species (ROS) level was determined, before and after oxidative stress induction with H(2)O(2). As an indicator of apoptosis, caspase 9 activity was measured.
resultsAll pretreatments reduced ROS generation. Four hour incubation with OOPE or GA completely inhibited ROS generation. Increases in caspase 9 activity by OOPE and GA pretreatment under harsh stress conditions were inhibited 92 and 67.8%, respectively.
conclusionsThese results suggest that OOPE and GA act as powerful antioxidants against oxidative stress and exert anti-apoptotic effects.
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