Evidence map›Paper›PMID 22086288›Full record

ArticleNature chemical biology2011

Lessons and revelations from biomimetic syntheses.

Mina Razzak, Jef K De Brabander

Abstract read
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In one paragraph

Article in Nature chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Comparative analysis of complanadine A total syntheses.Beilstein journal of organic chemistry · 2025
    Review
  6. Total syntheses of highly oxidativeBeilstein journal of organic chemistry · 2025
    Review
  7. Review
  8. Biogenetic space-guided synthesis of rearranged terpenoids.Chemical communications (Cambridge, England) · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Synthesis of 6,12-Disubstituted Methanodibenzo[Molecules (Basel, Switzerland) · 2019
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mina RazzakDepartment of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Jef K De Brabander

Funding

Chemistry and Biology of Salicylate Natural ProductsR01CA090349 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DE BRABANDER, JEF KAREL · 2001 to 2010
$2.6M
NCI NIH HHS CA 90349
6 · The paper itself

Abstract

Biomimetic synthesis describes the field of organic chemistry that aims to emulate the natural, biosynthetic processes toward natural products. As well as providing insight into how molecules are formed in nature, the benefits of this approach to total synthesis are numerous and extend beyond the gains typical of traditional synthesis. For example, using biosynthetic proposals to design a synthetic route can highlight alternative methods to the desired target. The pursuit of biomimetic syntheses also promotes the development of new reactions to prove or disprove a biosynthetic proposal or to unravel mechanistic implications of a proposed biosynthesis and can lead to the identification of new natural products. Here we look at some recent compelling examples and examine how biomimetic synthesis has led to the discovery of new procedures and principles that would not have been found by other approaches.

Indexed as

Chemistry Techniques, SyntheticBiomimetic MaterialsMolecular StructureStereoisomerism

Identifiers

PMID22086288

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.