ReviewProtoplasma2012
Nematode modulation of inflammatory bowel disease.
Review in Protoplasma, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Helminths in alternative therapeutics of inflammatory bowel disease.Intestinal research · 2025Review
- Whole-genome sequencing and analysis of Streptomyces strains producing multiple antinematode drugs.BMC genomics · 2022Article
- Immunomodulatory effect of Syphacia obvelata in treatment of experimental DSS-induced colitis in mouse model.Scientific reports · 2019Article
- Relationships Between Gastrointestinal Parasite Infections and the Fecal Microbiome in Free-Ranging Western Lowland Gorillas.Frontiers in microbiology · 2018Article
- Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance.Parasitology research · 2017Review
- Parasitic Nematode Immunomodulatory Strategies: Recent Advances and Perspectives.Pathogens (Basel, Switzerland) · 2016Review
- The relationship between intestinal parasites and some immune-mediated intestinal conditions.Gastroenterology and hepatology from bed to bench · 2015Review
- A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Epidemiological and clinical characteristics of inflammatory bowel diseases in Cairo, Egypt.World journal of gastroenterology · 2014Article
- Potential treatment of inflammatory bowel disease: a review of helminths therapy.Gastroenterology and hepatology from bed to bench · 2014Review
- Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice.PloS one · 2014Article
- Small intestinal nematode infection of mice is associated with increased enterobacterial loads alongside the intestinal tract.PloS one · 2013Article
- Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus.Seminars in immunopathology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) is a chronic disease arising due to a culmination of genetic, environmental, and lifestyle-associated factors and resulting in an excessive pro-inflammatory response to bacterial populations in the gastrointestinal tract. The prevalence of IBD in developing nations is relatively low, and it has been proposed that this is directly correlated with a high incidence of helminth infections in these areas. Gastrointestinal nematodes are the most prevalent parasitic worms, and they efficiently modulate the immune system of their hosts in order to establish chronic infections. Thus, they may be capable of suppressing unrelated inflammation in disorders such as IBD. This review describes how nematodes, or their products, suppress innate and adaptive pro-inflammatory immune responses and how the mechanisms involved in the induction of anti-nematode responses regulate colitis in experimental models and clinical trials with IBD patients. We also discuss how refinement of nematode-derived therapies should ultimately result in the development of potent new therapeutics of clinical inflammatory disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.