ArticleGenes & development2011
Competition for cofactor-dependent DNA binding underlies Hox phenotypic suppression.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Key homeobox transcription factors regulate the development of the firefly's adult light organ and bioluminescence.Nature communications · 2024Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
- The Hox protein conundrum: The "specifics" of DNA binding for Hox proteins and their partners.Developmental biology · 2021Review
- Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.Cell reports · 2018Article
- Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands.Biochimica et biophysica acta. General subjects · 2017Article
- Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS.PLoS genetics · 2017Article
- Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans.Neuron · 2015Article
- A competition mechanism for a homeotic neuron identity transformation in C. elegans.Developmental cell · 2015Article
- Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.PLoS genetics · 2014Article
- Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS.Developmental cell · 2014Article
- A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity.PLoS genetics · 2014Article
- Article
- SELEX-seq: a method for characterizing the complete repertoire of binding site preferences for transcription factor complexes.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Hox regulation of transcription: more complex(es).Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- PBX/extradenticle is required to re-establish axial structures and polarity during planarian regeneration.Development (Cambridge, England) · 2013Article
- Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.PLoS genetics · 2013Article
- Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors.PLoS biology · 2012Article
- Disentangling the many layers of eukaryotic transcriptional regulation.Annual review of genetics · 2012Review
- Variable motif utilization in homeotic selector (Hox)-cofactor complex formation controls specificity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Hox transcription factors exhibit an evolutionarily conserved functional hierarchy, termed phenotypic suppression, in which the activity of posterior Hox proteins dominates over more anterior Hox proteins. Using directly regulated Hox targeted reporter genes in Drosophila, we show that posterior Hox proteins suppress the activities of anterior ones by competing for cofactor-dependent DNA binding. Furthermore, we map a motif in the posterior Hox protein Abdominal-A (AbdA) that is required for phenotypic suppression and facilitates cooperative DNA binding with the Hox cofactor Extradenticle (Exd). Together, these results suggest that Hox-specific motifs endow posterior Hox proteins with the ability to dominate over more anterior ones via a cofactor-dependent DNA-binding mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.