ArticleToxicology letters2012
Mesothelial cell and anti-nuclear autoantibodies associated with pleural abnormalities in an asbestos exposed population of Libby MT.
Article in Toxicology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.Particle and fibre toxicology · 2022Pooled it
- Plasminogen Binding and Activation at the Mesothelial Cell Surface Promotes Invasion through a Collagen Matrix.International journal of molecular sciences · 2022Article
- Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan.International journal of molecular sciences · 2021Article
- Asbestos in High-Risk Communities: Public Health Implications.International journal of environmental research and public health · 2021Review
- Mechanisms of Environment-Induced Autoimmunity.Annual review of pharmacology and toxicology · 2021Article
- Perspective: The Lung, Particles, Fibers, Nanomaterials, and Autoimmunity.Frontiers in immunology · 2020Review
- Mesothelial cell autoantibodies upregulate transcription factors associated with fibrosis.Inhalation toxicology · 2017Article
- Principal components analysis to identify influences on research communication and engagement during an environmental disaster.BMJ open · 2016Article
- Libby amphibole-induced mesothelial cell autoantibodies bind to surface plasminogen and alter collagen matrix remodeling.Physiological reports · 2016Article
- Libby amphibole-induced mesothelial cell autoantibodies promote collagen deposition in mice.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Current Research and Opportunities to Address Environmental Asbestos Exposures.Environmental health perspectives · 2015Article
- Multiple pathway asbestos exposure assessment for a Superfund community.Journal of exposure science & environmental epidemiology · 2015Article
- Pesticides, chemical and industrial exposures in relation to systemic lupus erythematosus.Lupus · 2014Review
- Autoimmunity and asbestos exposure.Autoimmune diseases · 2014Review
- Asbestos-associated mesothelial cell autoantibodies promote collagen deposition in vitro.Inhalation toxicology · 2013Article
- Modeling environmental inhalant exposure in rheumatoid arthritis.Inhalation toxicologyReview
- Autoimmune markers for progression of Libby amphibole lamellar pleural thickening.Inhalation toxicologyArticle
- Amphibole asbestos as an environmental trigger for systemic autoimmune diseases.Autoimmunity reviewsReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Despite data linking amphibole asbestos exposure with production of autoantibodies, the role of autoantibodies in subsequent disease is unknown. Residents of Libby, Montana have experienced significant exposure to amphibole asbestos due to the mining of asbestos-contaminated vermiculite near the community over several decades. This population predominantly exhibits pleural disease, and an autoimmune-like disorder that has yet to be well defined. This study sought to determine whether autoantibodies from asbestos-exposed subjects were associated with pleural lesions. Serum samples of subjects from Libby were evaluated for anti-nuclear antibodies (ANA) and mesothelial cell autoantibodies (MCAA) using cell based ELISA. The presence of radiographic abnormalities detected during the time frame of serum collection was determined from screening records. In accord with previous studies, 61.3% (76/124) of the Libby samples were ANA positive, a frequency much higher than expected for a healthy population. The odds of having pleural or interstitial abnormalities in Libby was nearly 3.55 times greater for individuals that tested positive for ANA compared with individuals negative for ANA (p=0.004). MCAA were also detected at a strikingly high frequency (18.5%; 23/124) in samples from Libby. Individuals with MCAA had 4.9 times the risk of having pleural abnormalities compared to MCAA-negative subjects (p=0.044). In conclusion, ANA and MCAA were elevated in a study population that was known to have chronic exposure to asbestos, and these autoantibodies were associated with pleural abnormalities, the predominant finding in the asbestos-exposed population of Libby. Additional research is needed to determine the role these autoantibodies may play in pulmonary disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.