ArticleBiochimie2012
Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR.
Article in Biochimie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Probing Glycosaminoglycan-Protein Interactions: Applications of Surface Plasmon Resonance.Biosensors · 2026Review
- Anti-Inflammatory Effects of Polyglycerol Sulfates and Natural Polyanions in Type 2 Inflammation.Biomacromolecules · 2025Article
- Interleukin (IL)-7 Signaling in the Tumor Microenvironment.Advances in experimental medicine and biology · 2021Article
- LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofFrontiers in pharmacology · 2020Article
- Glycosaminoglycans from bovine eye vitreous humour and interaction with collagen type II.Glycoconjugate journal · 2018Article
- Impact of Temperature on Heparin and Protein Interactions.Biochemistry & physiology · 2018Article
- Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.Nature communications · 2017Article
- Interactions between nattokinase and heparin/GAGs.Glycoconjugate journal · 2015Article
- Article
- Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans.Biochimie · 2013Article
- Structural studies of the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans.Biochemistry · 2013Article
- Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway.Immunological reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Glycosaminoglycans (GAGs) interact with a number of cytokines and growth factors thereby playing an essential role in the regulation of many physiological processes. These interactions are important for both normal signal transduction and the regulation of the tissue distribution of cytokines/growth factors. In the present study, we employed surface plasmon resonance (SPR) spectroscopy to dissect the binding interactions between GAGs and murine and human forms of interleukin-7 (IL-7). SPR results revealed that heparin binds with higher affinity to human IL-7 than murine IL-7 through a different kinetic mechanism. The optimal oligosaccharide length of heparin for the interactions to human and murine IL-7 involves a sequence larger than a tetrasaccharide. These results further demonstrate that while IL-7 is principally a heparin/heparan sulfate binding protein, it also interacts with dermatan sulfate, chondroitin sulfates C, D, and E, indicating that this cytokine preferentially interacts with GAGs having a higher degree of sulfation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.