ArticleHearing research2012
Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells.
Article in Hearing research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Ginkgo biloba for tinnitus.The Cochrane database of systematic reviews · 2022Pooled it
- Cognitive behavioural therapy for tinnitus.The Cochrane database of systematic reviews · 2020Pooled it
- Sound therapy (using amplification devices and/or sound generators) for tinnitus.The Cochrane database of systematic reviews · 2018Pooled it
- Zinc supplementation for tinnitus.The Cochrane database of systematic reviews · 2016Pooled it
- Amplification with hearing aids for patients with tinnitus and co-existing hearing loss.The Cochrane database of systematic reviews · 2014Pooled it
- Impacts of Kv3.1 Channels on Action Potentials in Fusiform Neurons From the Dorsal Cochlear Nucleus of Mice Before and After Hearing Onset.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Association between serum α-Klotho levels and tinnitus stratified by sex and depression: A cross-sectional study from NHANES.Medicine · 2026Article
- Revealing Pathological Auditory Central Inhibition in Tinnitus Using Cortical Auditory Evoked Potentials Responses to Contralateral Acoustic Stimulation.Brain and behavior · 2025Article
- Mid-Infrared Photons Alleviate Tinnitus by Activating the KCNQ2 Channel in the Auditory Cortex.Research (Washington, D.C.) · 2024Article
- The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial.Frontiers in pharmacology · 2024Article
- Depolarization shift in the resting membrane potential of inferior colliculus neurons explains their hyperactivity induced by an acoustic trauma.Frontiers in neuroscience · 2023Article
- Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice.BMC biology · 2022Article
- What's the buzz? The neuroscience and the treatment of tinnitus.Physiological reviews · 2021Review
- Subjective tinnitus: lesion-induced pathological central homeostasis remodeling.Journal of otology · 2021Review
- Does hearing loss lead to dementia? A review of the literature.Hearing research · 2021Review
- Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021Article
- Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice.Frontiers in synaptic neuroscience · 2021Article
- Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Review
- Dorsal Cochlear Nucleus Fusiform-cell Plasticity is Altered in Salicylate-induced Tinnitus.Neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Acoustic over-exposure (AOE) triggers deafness in animals and humans and provokes auditory nerve degeneration. Weeks after exposure there is an increase in the cellular excitability within the dorsal cochlear nucleus (DCN) and this is considered as a possible neural correlate of tinnitus. The origin of this DCN hyperactivity phenomenon is still unknown but it is associated with neurons lying within the fusiform cell layer. Here we investigated changes of excitability within identified fusiform cells following AOE. Wistar rats were exposed to a loud (110 dB SPL) single tone (14.8 kHz) for 4 h. Auditory brainstem response recordings performed 3-4 days after AOE showed that the hearing thresholds were significantly elevated by about 20-30 dB SPL for frequencies above 15 kHz. Control fusiform cells fired with a regular firing pattern as assessed by the coefficient of variation of the inter-spike interval distribution of 0.19 ± 0.11 (n = 5). Three to four days after AOE, 40% of fusiform cells exhibited irregular bursting discharge patterns (coefficient of variation of the inter-spike interval distribution of 1.8 ± 0.6, n = 5; p < 0.05). Additionally the maximal firing following step current injections was reduced in these cells (from 83 ± 11 Hz, n = 5 in unexposed condition to 43 ± 6 Hz, n = 5 after AOE) and this was accompanied by an increased firing gain (from 0.09 ± 0.01 Hz/pA, n = 5 in unexposed condition to 0.56 ± 0.25 Hz/pA, n = 5 after AOE). Current and voltage clamp recordings suggest that the presence of bursts in fusiform cells is related to a down regulation of high voltage activated potassium currents. In conclusion we showed that AOE triggers deafness at early stages and this is correlated with profound changes in the firing pattern and frequency of the DCN major output fusiform cells. The changes here described could represent the initial network imbalance prior to the emergence of tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.