Trial reportThe New England journal of medicine2011
Comparative effectiveness of weight-loss interventions in clinical practice.
Trial report in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 392 papers, 20 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Practice-Based Opportunities for Weight Reduction Trial at Johns Hopkins
A Randomized Controlled Trial of Smart Management Strategy for Health (SMASH) Program for Overcoming Cancer Crisis and Growing Positively in Cancer Survivors
Weight-loss Treatment of Overweight / Obesity Patients Through Smartphone-assisted Dietary Coaching: A Pre-post Pilot Study
Evaluation of Performance and Safety of DTXO App, an Innovative Digital Therapy, in Improving Weight Loss and Weight-Loss Maintenance of Patients With Obesity by Increasing Their Adherence to Dietary, Exercise Regimens and Psycho-Behavioral Program
Effectiveness of the group-based nutrition education programme for obesity management in berguedà: a randomised clinical trial. energy2mob study
Who cites it
392 citing papers in PubMed, 20 syntheses or guidelines pooled it, 786 citations in OpenAlex.
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- A systematic review of influences on engagement with remote health interventions targeting weight management for individuals living with excess weight.International journal of obesity (2005) · 2025Pooled it
- Pooled it
- Digital versus nondigital behavioral interventions on cardiovascular risk reduction: systematic review and meta-analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Pooled it
- Pooled it
- Identifying the effective behaviour change techniques in nutrition and physical activity interventions for the treatment of overweight/obesity in post-treatment breast cancer survivors: a systematic review.Cancer causes & control : CCC · 2023Pooled it
- Weight regain and mental health outcomes following behavioural weight management programmes: A systematic review with meta-analyses.Clinical obesity · 2023Pooled it
- A systematic review of inequalities in the uptake of, adherence to, and effectiveness of behavioral weight management interventions in adults.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Does weight management research for adults with severe obesity represent them? Analysis of systematic review data.BMJ open · 2022Pooled it
- Effectiveness of weight management interventions for adults delivered in primary care: systematic review and meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2022Pooled it
- A systematic review of the use of dietary self-monitoring in behavioural weight loss interventions: delivery, intensity and effectiveness.Public health nutrition · 2021Pooled it
- The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis.Human reproduction update · 2021Pooled it
- Pooled it
- Guideline of the Brazilian Society of Cardiology on Telemedicine in Cardiology - 2019.Arquivos brasileiros de cardiologia · 2019Guideline
- Motivational interviewing in eHealth and telehealth interventions for weight loss: A systematic review.Preventive medicine · 2019Pooled it
- Pooled it
- Pooled it
- Obesity in the Workplace: Impact, Outcomes, and Recommendations.Journal of occupational and environmental medicine · 2018Guideline
- Reporting of Telehealth-Delivered Dietary Intervention Trials in Chronic Disease: Systematic Review.Journal of medical Internet research · 2017Pooled it
- A systematic review of lifestyle counseling for diverse patients in primary care.Preventive medicine · 2017Pooled it
332 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity and its cardiovascular complications are extremely common medical problems, but evidence on how to accomplish weight loss in clinical practice is sparse.
methodsWe conducted a randomized, controlled trial to examine the effects of two behavioral weight-loss interventions in 415 obese patients with at least one cardiovascular risk factor. Participants were recruited from six primary care practices; 63.6% were women, 41.0% were black, and the mean age was 54.0 years. One intervention provided patients with weight-loss support remotely--through the telephone, a study-specific Web site, and e-mail. The other intervention provided in-person support during group and individual sessions, along with the three remote means of support. There was also a control group in which weight loss was self-directed. Outcomes were compared between each intervention group and the control group and between the two intervention groups. For both interventions, primary care providers reinforced participation at routinely scheduled visits. The trial duration was 24 months.
resultsAt baseline, the mean body-mass index (the weight in kilograms divided by the square of the height in meters) for all participants was 36.6, and the mean weight was 103.8 kg. At 24 months, the mean change in weight from baseline was -0.8 kg in the control group, -4.6 kg in the group receiving remote support only (P<0.001 for the comparison with the control group), and -5.1 kg in the group receiving in-person support (P<0.001 for the comparison with the control group). The percentage of participants who lost 5% or more of their initial weight was 18.8% in the control group, 38.2% in the group receiving remote support only, and 41.4% in the group receiving in-person support. The change in weight from baseline did not differ significantly between the two intervention groups.
conclusionsIn two behavioral interventions, one delivered with in-person support and the other delivered remotely, without face-to-face contact between participants and weight-loss coaches, obese patients achieved and sustained clinically significant weight loss over a period of 24 months. (Funded by the National Heart, Lung, and Blood Institute and others; ClinicalTrials.gov number, NCT00783315.).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.