Evidence map›Paper›PMID 22085243›Full record

ReviewInfluenza and other respiratory viruses2012

Influenza neuraminidase.

Gillian M Air

Open access · greenAbstract readReview
In one paragraph

Review in Influenza and other respiratory viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 1 synthesis or guideline pooled it, 254 citations in OpenAlex.

  1. Pooled it
  2. Substitutions affecting the HA-NA-receptor balance preceded the emergence of the pandemic 2009 H1N1 virus.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Computational Pipeline for Accelerating the Design of Glycomimetics.Journal of chemical information and modeling · 2025
    Article
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  15. Review
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  17. Review
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  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gillian M AirDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Gillian-air@ouhsc.edu
University of Oklahoma Health Sciences Center · US

Funding

Structural Basis of Immune Recognition of Glycosylated AntigensU54GM062116 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI PAULSON, JAMES C · 2001 to 2010
$80.3M
Human & mouse antibodies against influenza virusR01AI050933 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AIR, GILLIAN M · 2003 to 2012
$2.9M
New Influenza A Neuraminidase Inhibitors for BiodefenseR01AI062950 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROUILLETTE, WAYNE J · 2005 to 2009
$1.5M
Human &mouse antibodies against influenza virusR21AI050933 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AIR, GILLIAN M. · 2002 to 2002
$330k
IMMUNE FUNCTION AND BIODEFENSE IN CHILDREN ELDERLY AND IMMUNOCOMPROMIS-266050026N01AI050026 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI THOMPSON, LINDA · 2006 to 2006
–
NIAID NIH HHS AI50933NIAID NIH HHS AI62950NIAID NIH HHS N01 AI050026NIAID NIH HHS N01-AI50026NIAID NIH HHS R01 AI050933NIAID NIH HHS R01 AI062950NIAID NIH HHS R21 AI050933NIGMS NIH HHS GM62116NIGMS NIH HHS U54 GM062116
6 · The paper itself

Abstract

Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase.

Indexed as

Antiviral AgentsEnzyme InhibitorsInfluenza VaccinesModels, MolecularNeuraminidaseOrthomyxoviridaeProtein ConformationViral ProteinsAntiviral AgentsEnzyme InhibitorsInfluenza VaccinesNeuraminidaseViral Proteins

Identifiers

PMID22085243
PMCPMC3290697
OpenAlexW2322798543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.