ArticleAnnals of human genetics2012
Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia.
Article in Annals of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.Journal of human genetics · 2023Pooled it
- A scoping review on cardiometabolic risk factors among Pacific Island populations and implications on future research in the region.American journal of epidemiology · 2026Article
- The Impact of Haplotypes of theNutrients · 2024Article
- Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals.Eating and weight disorders : EWD · 2020Article
- Splicing QTL of human adipose-related traits.Scientific reports · 2018Article
- A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations.International journal of obesity (2005) · 2013Article
- Obesity polymorphisms identified in genome-wide association studies interact with n-3 polyunsaturated fatty acid intake and modify the genetic association with adiposity phenotypes in Yup'ik people.Genes & nutrition · 2013Article
- Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.PloS one · 2013Article
- The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults.Indian journal of endocrinology and metabolism · 2012Article
- Epigenetics, and human biology and health responses to modernization in the Samoan archipelago.Collegium antropologicum · 2012Article
- Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study.American journal of human biology : the official journal of the Human Biology CouncilArticle
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Authors and funding
8 authors.
Funding
Abstract
The association between obesity and the fat mass and obesity-associated (FTO) gene has been widely replicated among Caucasian populations. The limited number of studies assessing its significance in Asian populations has been somewhat conflicting. We performed a genetic association study of 51 tagging, genome-wide association studies, and imputed single nucleotide polymorphisms with 12 measures of adiposity and skeletal robustness in two Samoan populations of Polynesia. We included 465 and 624 unrelated American Samoan and Samoan individuals, respectively; these populations derive from a single genetic background traced to Southeast Asia and represent one sociocultural unit, although they are economically disparate with distinct environmental exposures. American Samoans were significantly larger than Samoans in all measures of obesity and most measures of skeletal robustness. In separate analyses of American Samoa and Samoa, we found a total of 36 nominal associations between FTO variants and skeletal and obesity measures. The preponderance of these nominal associations (32 of 36) was observed in the Samoan population, and predominantly with skeletal rather than fat mass measures (28 of 36). All significance disappeared, however, following corrections for multiple testing. Based on these findings, it could be surmised that FTO is not likely a major obesity locus in Polynesian populations.
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