ArticleEplasty2011
The use of growth factors and other humoral agents to accelerate and enhance burn wound healing.
Article in Eplasty, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis.International wound journal · 2016Pooled it
- Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.Results and problems in cell differentiation · 2026Review
- Modifying Large Molecule Release from Hydrogels Using Microcapillary Channels Patterned with Microfibrous Templates.Polymers for advanced technologies · 2025Article
- Comparison of the effects of epidermal growth factor mesenchymal stem cell and silver sulfadiazine on burn stasis zone.Turkish journal of surgery · 2025Article
- Novel, Reproducible, Consortia Factors Derived from Adipose Stem Cells for Burn Wound Treatment.Stem cells and cloning : advances and applications · 2025Article
- The Use of Fast-Acting Insulin Topical Solution on Skin to Promote Surgical Wound Healing in Cats.Animals : an open access journal from MDPI · 2024Article
- Effects of dose-dependent chronic caffeine consumption in a rat burn wound model: Histopathological and immunohistochemical evaluation.Iranian journal of basic medical sciences · 2024Article
- Polysaccharide-based hydrogel enriched by epidermal growth factor peptide fragment for improving the wound healing process.Heliyon · 2023Article
- An Overview of Recent Developments in the Management of Burn Injuries.International journal of molecular sciences · 2023Review
- Recent advances in decellularized biomaterials for wound healing.Materials today. Bio · 2023Review
- [Influence of autologous adipose stem cell matrix gel on wound healing and scar hyperplasia of full-thickness skin defects in rabbit ears].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Intra-amniotic mesenchymal stem cell therapy improves the amniotic fluid microenvironment in rat spina bifida aperta fetuses.Cell proliferation · 2023Article
- Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.Burns : journal of the International Society for Burn Injuries · 2020Review
- Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing.Frontiers in physiology · 2020Review
- Role of growth factors and cytokines in diabetic foot ulcer healing: A detailed review.Reviews in endocrine & metabolic disorders · 2019Review
- Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration.Journal of materials science. Materials in medicine · 2018Article
- In vitro evaluation of a basic fibroblast growth factor-containing hydrogel toward vocal fold lamina propria scar treatment.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update.Frontiers in immunology · 2018Review
- Evaluation of phytochemicals, antioxidant and burn wound healing activities ofIranian journal of basic medical sciences · 2017Article
- Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling.Frontiers in immunology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCertain cytokines, especially those known as growth factors, have been demonstrated to mediate or modulate burn wound healing. Experimental and clinical evidence suggests that there are therapeutic advantages to the wound healing process when these agents are utilized. Positive effects have been reported for 4 types of wounds seen in the burn patient: partial-thickness wounds, full-thickness wounds, interstices of meshed skin grafts, and skin graft donor sites.
methodsA comprehensive literature search was performed using the MEDLINE, Ovid, and Web of Science databases to identify pertinent articles regarding growth factors and other cytokines in burns and wound healing.
resultsThe current knowledge about cytokine growth factors and their potential therapeutic applications in burn wound healing are discussed and reviewed.
conclusionsPlatelet-derived growth factor, fibroblast growth factors, epidermal growth factors, transforming growth factor alpha, vascular endothelial growth factor, insulin-like growth factor I, nerve growth factor, transforming growth factor beta, granulocyte-macrophage colony-stimulating factor, and amnion-derived cellular cytokine solution have all been suggested to enhance the rate and quality of healing in 1 or more of these wounds encountered in burn care.
Identifiers
22084646PMC3212033W1509212623What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.