ArticleFrontiers in behavioral neuroscience2011
Modulation of neuronal signal transduction and memory formation by synaptic zinc.
Article in Frontiers in behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment.Substance abuse treatment, prevention, and policy · 2023Trial
- Zinc as a master regulator of intracellular organelle homeostasis.Experimental & molecular medicine · 2026Review
- Zinc Coordination by Thymosin β4: Structural Determinants and Functional Implications.International journal of molecular sciences · 2026Article
- Quantitative Control of ZnAnalytical chemistry · 2025Article
- Identification of hippocampal area CA2 in hamster and vole brain.The Journal of comparative neurology · 2024Article
- Identification of hippocampal area CA2 in hamster and vole brain.bioRxiv : the preprint server for biology · 2024Article
- ZniScience · 2022Article
- Anatomical and molecular features of the amygdalohippocampal transition area and its role in social and emotional behavior processes.Neuroscience and biobehavioral reviews · 2022Review
- Neuronal signalling of zinc: from detection and modulation to function.Open biology · 2022Review
- Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders.International journal of molecular sciences · 2022Review
- Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.International journal of environmental research and public health · 2021Review
- Article
- Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination.Metallomics : integrated biometal science · 2020Article
- Article
- Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model.Frontiers in aging neuroscience · 2019Article
- Physiological Concentrations of Zinc Have Dual Effects on P2X Myenteric Receptors of Guinea Pig.Cellular and molecular neurobiology · 2018Article
- Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link.International journal of molecular sciences · 2018Article
- Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice.Neurochemical research · 2017Article
- Supplementation with zinc in rats enhances memory and reverses an age-dependent increase in plasma copper.Behavioural brain research · 2017Article
- Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over 50 years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathways implicated in neuroplasticity, and others that shed some light on the elusive role of synaptic zinc in learning and memory. Recent behavioral studies using knock-out mice for the synapse-specific zinc transporter ZnT-3 indicate that vesicular zinc is required for the formation of memories dependent on the hippocampus and the amygdala, two brain centers that are prominently innervated by zinc-rich fibers. A common theme emerging from this research is the activity-dependent regulation of the Erk1/2 mitogen-activated-protein kinase pathway by synaptic zinc through diverse mechanisms in neurons. Here we discuss current knowledge on how synaptic zinc may play a role in cognition through its impact on neuronal signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.