ArticleInternational journal of tryptophan research : IJTR2009
Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model.
Article in International journal of tryptophan research : IJTR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Trial
- A Jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging.The journal of nutrition, health & aging · 2013Trial
- Insomnia-Associated Circadian and Thrombotic Alterations Coincide with Morning Cardiac Vulnerability.ACS pharmacology & translational science · 2026Article
- Photoperiod as a neuroendocrine regulator: A review on pineal-melatonin signaling and physiological plasticity in poultry.Poultry science · 2026Review
- Article
- Impact of Thermal Processing and Carbohydrate Carriers on Amino Acids, Sugars, Phenolic Compounds, and Maillard Reaction Markers Relevant to Nutritional Quality and Safety ofMolecules (Basel, Switzerland) · 2025Article
- Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review.International journal of molecular sciences · 2025Review
- Using a Multi-Attribute Decision-Making Method to Evaluate the Effect of in Ovo Injection of Valine and Tryptophan on the Growth Performance of Broiler Chickens.Veterinary medicine and science · 2025Article
- A Transcriptomics Approach to Unveil the Antioxidant Effects of Tryptophan on Oocyte Quality Under Oxidative Stress in Pigs.Biomolecules · 2025Article
- The Mechanisms of Magnesium in Sleep Disorders.Nature and science of sleep · 2025Review
- Effect of Rumen-Protected L-Tryptophan or L-Ascorbic Acid on Plasma Metabolites and Milk Production Characteristics of Lactating Holstein Cows during Summer Conditions.Animals : an open access journal from MDPI · 2024Article
- Standardized ileal digestible tryptophan and lysine affects the eating and sleeping behavior of 15-30 kg barrows.Tropical animal health and production · 2023Article
- Article
- Polyphenol and Tryptophan Contents of Purple Corn (Plants (Basel, Switzerland) · 2023Article
- Quantitative analysis of disease-related metabolic dysregulation of human microbiota.iScience · 2023Article
- Maternal Western-style diet reduces social engagement and increases idiosyncratic behavior in Japanese macaque offspring.Brain, behavior, and immunity · 2022Article
- Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers.Diagnostics (Basel, Switzerland) · 2022Review
- An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway.International journal of molecular sciences · 2022Review
- The Influence of Maternal Metabolic State and Nutrition on Offspring Neurobehavioral Development: A Focus on Preclinical Models.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present review we summarize the relationship between the amino acid, tryptophan, the neurotransmitter, serotonin, and the indole, melatonin, with the rhythms of sleep/wake and the immune response along with the possible connections between the alterations in these rhythms due to aging and the so-called "serotonin and melatonin deficiency state." The decrease associated with aging of the brain and circulating levels of serotonin and melatonin seemingly contributes to the alterations of both the sleep/wake cycle and the immune response that typically accompany old age. The supplemental administration of tryptophan, e.g. the inclusion of tryptophan-enriched food in the diet, might help to remediate these age-related alterations due to its capacity of raise the serotonin and melatonin levels in the brain and blood. Herein, we also summarize a set of studies related to the potential role that tryptophan, and its derived product melatonin, may play in the restoration of the aged circadian rhythms of sleep/wake and immune response, taking the ringdove (Streptopeliarisoria) as a suitable model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.