ArticleEvolutionary bioinformatics online2011
Characterization and inference of gene gain/loss along burkholderia evolutionary history.
Article in Evolutionary bioinformatics online, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Phylogenetic analysis of the bacterial intracellular R-body killer proteins indicates extensive horizontal gene transfer and signature Reb sequence motifs.BMC genomics · 2026Article
- Evolutionary mechanisms underlying bacterial adaptation to the plant environment.FEMS microbiology reviews · 2026Review
- Complete Genome Sequence of Massilia oculi sp. nov. CCUG 43427Current microbiology · 2019Article
- Tal1Frontiers in microbiology · 2019Article
- The complete genome of Burkholderia phenoliruptrix strain BR3459a, a symbiont of Mimosa flocculosa: highlighting the coexistence of symbiotic and pathogenic genes.BMC genomics · 2014Article
- Article
- Global patterns of protein domain gain and loss in superkingdoms.PLoS computational biology · 2014Article
- Updated clusters of orthologous genes for Archaea: a complex ancestor of the Archaea and the byways of horizontal gene transfer.Biology direct · 2012Article
- An objective approach for Burkholderia pseudomallei strain selection as challenge material for medical countermeasures efficacy testing.Frontiers in cellular and infection microbiology · 2012Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comparative analysis of 60 complete Burkholderia genomes was conducted to obtain insight in the evolutionary history behind the diversity and pathogenicity at species level. A concatenated multiprotein phyletic pattern and a dataset with Burkholderia clusters of orthologous genes (BuCOGs) were constructed. The extent of horizontal gene transfer (HGT) was assessed using a Markov based probabilistic method. A reconstruction of the gene gains and losses history shows that more than half of the Burkholderia genes families are inferred to have experienced HGT at least once during their evolution. Further analysis revealed that the number of gene gain and loss was correlated with the branch length. Genomic islands (GEIs) analysis based on evolutionary history reconstruction not only revealed that most genes in ancient GEIs were gained but also suggested that the fraction of the genome located in GEIs in the small chromosomes is higher than in the large chromosomes in Burkholderia. The mapping of coexpressed genes onto biological pathway schemes revealed that pathogenicity of Burkholderia strains is probably mainly determined by the gained genes in its ancestor. Taken together, our results strongly support that gene gain and loss especially in ancient evolutionary history play an important role in strain divergence, pathogenicity determinants of Burkholderia and GEIs formation.
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