Evidence map›Paper›PMID 22084422›Full record

ReviewGenetics2011

Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.

Steven Hahn, Elton T Young

Abstract readReview
In one paragraph

Review in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed.

  1. Article
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143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steven HahnFred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. shahn@fhcrc.org
Elton T Young

Funding

MOLECULAR ANALYSIS OF RNAPIII TRANSCRIPTION INITIATIONR01GM053451 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HAHN, STEVEN M · 1995 to 2020
$11.4M
Mechanisms of eukaryotic transcription activationR01GM075114 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HAHN, STEVEN M · 2005 to 2020
$7.9M
GENETIC REGULATION OF ALCOHOL METABOLISM IN YEASTR01GM026079 · NIGMS · UNIVERSITY OF WASHINGTON · PI YOUNG, ELTON T. · 1985 to 2013
$6.1M
NIGMS NIH HHS R01 GM026079NIGMS NIH HHS R01 GM053451NIGMS NIH HHS R01 GM075114
6 · The paper itself

Abstract

Here we review recent advances in understanding the regulation of mRNA synthesis in Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been conserved in all eukaryotes, and budding yeast has been at the forefront in the discovery and dissection of these conserved mechanisms. Topics covered include upstream activation sequence and promoter structure, transcription factor classification, and examples of regulated transcription factor activity. We also examine advances in understanding the RNA polymerase II transcription machinery, conserved coactivator complexes, transcription activation domains, and the cooperation of these factors in gene regulatory mechanisms.

Indexed as

Transcription Initiation SiteAmino Acid SequenceAnimalsGene Expression Regulation, FungalHumansMolecular Sequence DataSaccharomyces cerevisiaeTranscriptional ActivationTranscription FactorsTranscription, GeneticTranscription Factors

Identifiers

PMID22084422
PMCPMC3213380

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.