Evidence map›Paper›PMID 22084388›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011

The Renaissance or the cuckoo clock.

Jonathon Pines, Iain Hagan

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Repurposing Cell Cycle Oscillators for Multiciliated Cell Differentiation.Advances in experimental medicine and biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. The biochemistry of mitosis.Cold Spring Harbor perspectives in biology · 2015
    Review
  9. Article
  10. Polo-like kinases: structural variations lead to multiple functions.Nature reviews. Molecular cell biology · 2014
    Review
  11. Article
  12. Temporal control of epigenetic centromere specification.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012
    Review
  13. Article
  14. The cell cycle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathon PinesGurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK. jp103@cam.ac.uk
Iain Hagan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

'…in Italy, for thirty years under the Borgias, they had warfare, terror, murder and bloodshed, but they produced Michelangelo, Leonardo da Vinci and the Renaissance. In Switzerland, they had brotherly love, they had five hundred years of democracy and peace-and what did that produce? The cuckoo clock'. Orson Welles as Harry Lime: The Third Man. Orson Welles might have been a little unfair on the Swiss, after all cuckoo clocks were developed in the Schwartzwald, but, more importantly, Swiss democracy gives remarkably stable government with considerable decision-making at the local level. The alternative is the battling city-states of Renaissance Italy: culturally rich but chaotic at a higher level of organization. As our understanding of the cell cycle improves, it appears that the cell is organized more along the lines of Switzerland than Renaissance Italy, and one major challenge is to determine how local decisions are made and coordinated to produce the robust cell cycle mechanisms that we observe in the cell as a whole.

Indexed as

Cell CycleDNA ReplicationAnaphase-Promoting Complex-CyclosomeAnimalscdc25 PhosphatasesCell Cycle ProteinsCentrosomeCyclin BCyclin-Dependent KinasesFungal ProteinsHumansKinetochoresM Phase Cell Cycle CheckpointsSignal TransductionUbiquitin-Protein Ligase ComplexesYeastsAnaphase-Promoting Complex-Cyclosomecdc25 PhosphatasesCell Cycle ProteinsCyclin BCyclin-Dependent KinasesFungal ProteinsUbiquitin-Protein Ligase Complexes

Identifiers

PMID22084388
PMCPMC3203460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.