ArticlePediatrics2011
Leveraging state immunization information systems to measure the effectiveness of rotavirus vaccine.
Article in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of Methodology.Epidemiology (Cambridge, Mass.) · 2020Pooled it
- Population effectiveness of the pentavalent and monovalent rotavirus vaccines: a systematic review and meta-analysis of observational studies.BMC infectious diseases · 2017Pooled it
- A Retrospective Test-Negative Case-Control Study to Evaluate Influenza Vaccine Effectiveness in Preventing Hospitalizations in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012-2017.Pediatric blood & cancer · 2020Trial
- Evaluating Partial Series Childhood Vaccination Services in a Mobile Clinic Setting.Clinical pediatrics · 2020Article
- A decade of experience with rotavirus vaccination in the United States - vaccine uptake, effectiveness, and impact.Expert review of vaccines · 2018Review
- Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia.Ethnicity & health · 2017Article
- Rotavirus and Norovirus in Pediatric Healthcare-Associated Gastroenteritis.Open forum infectious diseases · 2016Article
- Rotavirus vaccine effectiveness in Hong Kong children.Vaccine · 2016Article
- Use of Patients With Diarrhea Who Test Negative for Rotavirus as Controls to Estimate Rotavirus Vaccine Effectiveness Through Case-Control Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Article
- Association between mixed rotavirus vaccination types of infants and rotavirus acute gastroenteritis.Vaccine · 2015Article
- Rotavirus vaccines in routine use.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Review
- Effectiveness and impact of rotavirus vaccines in the United States - 2006-2012.Expert review of vaccines · 2014Review
- Effectiveness of 2 rotavirus vaccines against rotavirus disease in Taiwanese infants.The Pediatric infectious disease journal · 2014Article
- Rotavirus vaccines: current status and future considerations.Human vaccines & immunotherapeutics · 2014Review
- Article
- Comparison of 2 assays for diagnosing rotavirus and evaluating vaccine effectiveness in children with gastroenteritis.Emerging infectious diseases · 2013Article
- Effectiveness of monovalent and pentavalent rotavirus vaccine.Pediatrics · 2013Article
- Effectiveness of pentavalent and monovalent rotavirus vaccines in concurrent use among US children <5 years of age, 2009-2011.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveElectronic immunization information systems (IISs) are now established in almost all US states. We used the IIS in Minnesota, Georgia, and Connecticut for immunization data and as the source of 1 of 2 control groups to measure pentavalent rotavirus vaccine (RV5) effectiveness (VE) using case-control methodology. PATIENTS AND
methodsCase-subjects were vaccine-eligible children who presented to 1 of 5 hospitals or emergency departments with gastroenteritis and had rotavirus antigen detected in stool during any of 3 rotavirus seasons (2007-2009). Two control groups were used: children with gastroenteritis who tested negative for rotavirus and children from the IIS matched by zip code and birth date. In Minnesota and Georgia, immunization records for rotavirus-positive and -negative children were also obtained from providers.
resultsOverall, 402 (96%) rotavirus case-subjects and 825 (97%) rotavirus-negative controls who met eligibility criteria were found in the IISs. Ten IIS controls were identified for each case. VE estimates for RV5 were similar across control groups, immunization data sources, and states. VE point estimates for 3 vs 0 doses were 89% to 94% among children aged 8 months or older and 86% to 92% among those aged 24 months or older. VE for 2 doses was ≥90% among children aged 8 months or older, and VE for 1 dose was 66% among those aged 6 weeks through 5 months.
conclusionsThree RV5 doses confer sustained protection against rotavirus disease during the first 3 years of life in US children. Two RV5 doses also seem to provide good protection. IISs can be valuable tools for assessing the effectiveness of vaccines administered to young children.
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Registered trials
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