ArticleGenome biology and evolution2011
Extensive genomic variation within clonal complexes of Neisseria meningitidis.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Genetic characterization ofFrontiers in cellular and infection microbiology · 2024Article
- Rapid identification, capsular typing and molecular characterization of Streptococcus pneumoniae by using whole genome nanopore sequencing.BMC microbiology · 2020Article
- Complete genome and methylome analysis of Neisseria meningitidis associated with increased serogroup Y disease.Scientific reports · 2020Article
- The comparative population genetics ofPeerJ · 2019Article
- Interconnected clusters of invasive meningococcal disease due toEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Neisseria genomics: current status and future perspectives.Pathogens and disease · 2017Review
- UnravelingF1000Research · 2017Review
- Genomic Investigation Reveals Highly Conserved, Mosaic, Recombination Events Associated with Capsular Switching among Invasive Neisseria meningitidis Serogroup W Sequence Type (ST)-11 Strains.Genome biology and evolution · 2016Article
- Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.Scientific reports · 2016Article
- Article
- Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study.The Lancet. Infectious diseases · 2015Article
- Genomic Analysis of the Evolution and Global Spread of Hyper-invasive Meningococcal Lineage 5.EBioMedicine · 2015Article
- Metabolism and virulence in Neisseria meningitidis.Frontiers in cellular and infection microbiology · 2014Review
- Routine vaccination against MenB: considerations for implementation.Human vaccines & immunotherapeutics · 2014Article
- A multi-component meningococcal serogroup B vaccine (4CMenB): the clinical development program.Drugs · 2014Review
- Genomic comparative analysis and gene function prediction in infectious diseases: application to the investigation of a meningitis outbreak.BMC infectious diseases · 2013Article
- Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease.Microbiology and molecular biology reviews : MMBR · 2013Review
- Dialects of the DNA uptake sequence in Neisseriaceae.PLoS genetics · 2013Article
- Unique secreted-surface protein complex of Lactobacillus rhamnosus, identified by phage display.MicrobiologyOpen · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningococcal disease is a widely distributed complex disease affecting all age categories. It can cause severe meningitis and septicemia, especially in unvaccinated infants and young children. The causative agent, Neisseria meningitidis (Nm), can be phenotypically and genetically differentiated into serogroups and sequence types (STs) and has a highly dynamic population structure. To obtain a deeper understanding of the epidemiology of Nm, we sequenced seven Nm genomes. Large-scale genomic analysis was conducted with these 7 Nm genomes, 27 additional Nm genomes from GenBank, and 4 other Neisseria genomes. We observed extensive homologous recombination in all gene functional categories among different Nm genomes. Homologous recombination is so frequent that it has resulted in numerous chimeric open reading frames, including genes in the capsule biosynthesis cluster and loci targeted by commercial vaccines. Our results reveal that, despite widespread use, evolutionary relationships inferred from the standard seven-gene multilocus sequence typing (MLST) method could not predict virulence gene content or strain phenotype. In fact, up to 28% of the virulence-associated genes could differ between strains of identical STs. Consistent with previous studies, we found that allelic recombination is also associated with alterations in antibiotic susceptibility. Overall, these findings emphasize the extensive genomic plasticity of Nm and the limitations of standard molecular methods to quantify this genotypic and phenotypic diversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.