ArticleThe Journal of cell biology2011
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
Article in The Journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Photobiology in ophthalmology: from evolutionary adaptation to translational therapeutics.Japanese journal of ophthalmology · 2026Review
- Hypoxia-Driven Histone Modifications Govern Gene Regulation for Mature Eye Lens Formation.Investigative ophthalmology & visual science · 2025Article
- The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis.Cellular and molecular life sciences : CMLS · 2023Review
- Lactoferrin Has a Therapeutic EffectFrontiers in pharmacology · 2020Article
- Assessment and Characterization of Hyaloid Vessels in Mice.Journal of visualized experiments : JoVE · 2019Article
- HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model.PeerJ · 2019Article
- Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy.Scientific reports · 2018Article
- Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism.Progress in retinal and eye research · 2018Review
- Epithelial-mesenchymal transition of the retinal pigment epithelium causes choriocapillaris atrophy.Histochemistry and cell biology · 2016Article
- βA3/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye.Biochimica et biophysica acta · 2016Review
- Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.Investigative ophthalmology & visual science · 2014Article
- Targeted deletion of Vegfa in adult mice induces vision loss.The Journal of clinical investigation · 2012Article
- Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes.Molecular vision · 2012Article
- Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Successful transition from embryonic to adult circulation is critical for survival of mammalian organisms. This shift occurs in the central cardiovascular circulation and in the eye as oxygen tension increases. However, its regulation is not well understood. We have used combinatorial gene deletion and overexpression assays to assess the effect of astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and Vegf on the normal regression of the hyaloidal vessels, the fetal ocular circulation system. Astrocytic Vhl deletion induced accelerated hyaloidal regression and subsequent massive secondary outgrowth. Combinatorial gene deletion involving Vhl, Hif-αs, and Vegf genes revealed that HIF-2α/vascular endothelial growth factor signaling induces secondary outgrowth in Vhl mutants. Conversely, HIF-1α regulated macrophage migration inhibitory factor and promoted macrophage infiltration that accelerates hyaloidal vessel regression. The phenotype observed in Vhl mutants strongly resembles human persistent hyperplastic primary vitreous cases and may provide insights into vascular remodeling mechanisms in other systems.
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Registered trials
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