ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2011
Real-time ophthalmoscopic findings of superselective intraophthalmic artery chemotherapy in a nonhuman primate model.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Rabbit Model of Intra-Arterial Chemotherapy Toxicity Demonstrates Retinopathy and Vasculopathy Related to Drug and Dose, Not Procedure or Approach.Investigative ophthalmology & visual science · 2019Article
- Fluorescein angiography findings in both eyes of a unilateral retinoblastoma case during intra-arterial chemotherapy with melphalan.International journal of ophthalmology · 2019Article
- Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma.Investigative ophthalmology & visual science · 2018Article
- Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.Mini reviews in medicinal chemistry · 2016Review
- Outcome of retinoblastoma following limited sessions of intra-arterial chemotherapy in iran.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2014Article
- Electroretinogram monitoring of dose-dependent toxicity after ophthalmic artery chemosurgery in retinoblastoma eyes: six year review.PloS one · 2014Article
- Novel quinic acid derivative KZ-41 prevents retinal endothelial cell apoptosis without inhibiting retinoblastoma cell death through p38 signaling.Investigative ophthalmology & visual science · 2013Article
- Ocular tumors: Triumphs, challenges and controversies.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2013Article
- Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings.JAMA ophthalmology · 2013Article
- Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.Eye (London, England) · 2013Review
- Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy: comparing ophthalmic artery diameters.Investigative ophthalmology & visual science · 2012Article
- Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis.Investigative ophthalmology & visual science · 2012Article
- Retinal Optical Coherence Tomography Angiography Findings following Retinoblastoma Treatment by Chemotherapy.Journal of current ophthalmologyArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo report real-time ophthalmoscopic findings during superselective intraophthalmic artery chemotherapy (SSIOAC) in a nonhuman primate model.
methodsSix adult male Rhesus macaques (Macacca mulatta) were randomly assigned to 1 of 2 treatment cohorts: melphalan (5 mg/30 mL) or carboplatin (30 mg/30 mL). Each animal underwent 3 separate SSIOAC procedures at 3-week intervals. Digital retinal images were obtained during each infusion. Intravenous fluorescein angiography was performed immediately after each procedure.
resultsAll SSIOAC procedures were successfully completed. Toxicities were equally distributed between drug cohorts. Systemic toxicities included mild bone marrow suppression in all animals and anorexia in 1. One animal had greater than 50% narrowing of the treated ophthalmic artery after its second infusion. All 18 procedures (100%) resulted in pulsatile optic nerve and choroid blanching, retinal artery narrowing, and retinal edema. Of the 18 procedures, retinal artery sheathing was found during 17 (94%), and retinal artery precipitates were seen in 10 (56%); choroidal hypoperfusion was seen by fluorescein angiogram in 18 (100%).
conclusionReal-time ophthalmic investigations are useful and, in our nonhuman primate model, indicate prevalent, acute ocular vascular toxicities during SSIOAC. CLINICAL RELEVANCE: Real-time retinal imaging is feasible in a nonhuman primate model of SSIOAC. Application to SSIOAC in children may shed insight into reported vascular toxicities.
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