ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2012
Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
108 citing papers in PubMed.
- Two distributed enhancers of Sox17 additively regulate the developmental fate of bipotential ventral pancreato-biliary progenitor cells.Development (Cambridge, England) · 2026Article
- Chromosomal inversions modulate 3D chromatin interactions and regulatory architecture inResearch square · 2026Article
- Genome architecture shapes the evolutionary origins of redundant enhancers in fly and mouse.bioRxiv : the preprint server for biology · 2026Article
- Compensatory action of different types of cis-regulatory elements buffers the striped expression of Drosophila pair-rule genes.Development (Cambridge, England) · 2025Article
- CFTR Gene Regulation in Human Pancreatic Duct, Bile Duct and Sweat Gland Epithelial Cells.Journal of cellular and molecular medicine · 2025Article
- A Notch signal required for a morphological novelty inScience advances · 2025Article
- Two coacting shadow enhancers regulate twin of eyeless expression during early Drosophila development.Genetics · 2025Article
- Understanding Transcriptional Regulatory Redundancy by Learnable Global Subset Perturbations.Proceedings of machine learning research · 2024Article
- Notch-Dependent Expression of theGenes · 2024Article
- Review
- What is an enhancer?BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.Nature genetics · 2023Article
- Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line.Communications biology · 2023Article
- Changes in locus wide repression underlie the evolution of Drosophila abdominal pigmentation.PLoS genetics · 2023Article
- Gene silencing dynamics are modulated by transiently active regulatory elements.Molecular cell · 2023Article
- On the impermanence of species: The collapse of genetic incompatibilities in hybridizing populations.Evolution; international journal of organic evolution · 2022Article
- Epigenetics, Enhancer Function and 3D Chromatin Organization in Reprogramming to Pluripotency.Cells · 2022Review
- Review
- Analysis of the landscape of human enhancer sequences in biological databases.Computational and structural biotechnology journal · 2022Article
- Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1.PLoS genetics · 2022Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding questions about "shadow enhancers", quasi-redundant cis-regulatory elements, and their proposed roles in transcriptional control. Questions include: What exactly are shadow enhancers? How many genes have shadow/redundant/distributed enhancers? How redundant are these elements? What is the function of distributed enhancers? How modular are enhancers? Is it useful to study a single enhancer in isolation? In addition, a revised definition of "shadow enhancers" is proposed, and possible mechanisms of shadow enhancer function and evolution are discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.