Evidence map›Paper›PMID 22083666›Full record

ArticleHead & neck2012

Murine model of neuromuscular electrical stimulation on squamous cell carcinoma: potential implications for dysphagia therapy.

Gary Linkov, Ryan C Branski, Milan Amin, Natalya Chernichenko, Chun-Hao Chen, Gad Alon, Susan Langmore, Richard J Wong, Dennis H Kraus

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gary LinkovHead and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Ryan C Branski
Milan Amin
Natalya Chernichenko
Chun-Hao Chen
Gad Alon
Susan Langmore
Richard J Wong
Dennis H Kraus
Memorial Sloan Kettering Cancer Center · USNew York University · USBoston Medical Center · USUniversity of Maryland, Baltimore · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
HEAD AND NECK TRAINING PROGRAM SURGICAL ONCOLOGYT32CA009685 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FAGIN, JAMES A, WONG, RICHARD J · 1992 to 2022
$3.6M
Efficacy of Electrical Stimulation for Dysphagia in Head & Neck Cancer PatientsR01CA120950 · NCI · BOSTON MEDICAL CENTER · PI LANGMORE, SUSAN E · 2007 to 2011
$2.6M
NCI NIH HHS P30 CA008748NCI NIH HHS P30-CA008748NCI NIH HHS R01 CA120950NCI NIH HHS R0I CA 120950-05NCI NIH HHS T32 CA009685
6 · The paper itself

Abstract

backgroundDysphagia is a potential consequence of treatment for head and neck cancer. Neuromuscular electrical stimulation (NMES) has evolved as a treatment option, with the goal of improved swallow function in patients with chronic dysphagia. However, the effects of NMES on tumorigenicity are unknown and often confound the initiation of this therapy, potentially limiting its efficacy in treating patients with head and neck cancer.

methodsSquamous cell carcinoma was grown in the flank of athymic, nude mice. Mice were randomized into treatment and control groups; the experimental group received daily NMES directly to the flank for 8 days.

resultsTumor volumes, recorded on days 0, 3, 7, and 10, demonstrated no significant differences between groups on each day of measurement. Immunohistochemical analysis of apoptosis, proliferation, and vascularization also failed to demonstrate statistically significant differences between treated and untreated groups.

conclusionsNMES does not promote the growth of underlying tumor in our model. These data may provide preliminary evidence that applying electrical stimulation over the muscles of the anterior neck does not increase the risk of tumorigenicity. Early initiation of NMES in this challenging population may be feasible from an oncologic standpoint.

Indexed as

AnimalsBiopsy, NeedleCarcinoma, Squamous CellDeglutition DisordersDisease Models, AnimalElectric Stimulation TherapyHead and Neck NeoplasmsImmunohistochemistryMaleMiceMice, NudeRandom AllocationSensitivity and SpecificityTreatment OutcomeTumor Burden

Identifiers

PMID22083666
PMCPMC3781933
OpenAlexW2086394088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.