ArticleAntimicrobial agents and chemotherapy2012
The class A β-lactamase FTU-1 is native to Francisella tularensis.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Clinical Characteristics and Treatment Strategies in a Cohort of Patients with Tularemia: A Retrospective Multicenter Analysis of 65 Cases in Germany.Antibiotics (Basel, Switzerland) · 2025Article
- Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.Microorganisms · 2024Review
- Antimicrobial resistance gene lack in tick-borne pathogenic bacteria.Scientific reports · 2023Article
- Tularemia treatment: experimental and clinical data.Frontiers in microbiology · 2023Review
- Characterization of threeAccess microbiology · 2023Article
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- CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The G132S Mutation Enhances the Resistance ofBiochemistry · 2021Article
- Genetic Determinants of Antibiotic Resistance inFrontiers in microbiology · 2021Review
- Virulence ofMicroorganisms · 2020Article
- Seawater-Associated Highly Pathogenic Francisella hispaniensis Infections Causing Multiple Organ Failure.Emerging infectious diseases · 2020Article
- Phylogeography and Genetic Diversity ofFrontiers in microbiology · 2020Article
- β-Lactamases and β-Lactamase Inhibitors in the 21st Century.Journal of molecular biology · 2019Review
- Article
- Review
- A Structure-Based Classification of Class A β-Lactamases, a Broadly Diverse Family of Enzymes.Clinical microbiology reviews · 2016Review
- Structural and Functional Aspects of Class A Carbapenemases.Current drug targets · 2016Review
- Role of the Outer Membrane and Porins in Susceptibility of β-Lactamase-Producing Enterobacteriaceae to Ceftazidime-Avibactam.Antimicrobial agents and chemotherapy · 2015Article
- Bis-indolic compounds as potential new therapeutic alternatives for tularaemia.Frontiers in cellular and infection microbiology · 2014Article
- New therapeutic approaches for treatment of tularaemia: a review.Frontiers in cellular and infection microbiology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The class A β-lactamase FTU-1 produces resistance to penicillins and ceftazidime but not to any other β-lactam antibiotics tested. FTU-1 hydrolyzes penicillin antibiotics with catalytic efficiencies of 10(5) to 10(6) M(-1) s(-1) and cephalosporins and carbapenems with catalytic efficiencies of 10(2) to 10(3) M(-1) s(-1), but the monobactam aztreonam and the cephamycin cefoxitin are not substrates for the enzyme. FTU-1 shares 21 to 34% amino acid sequence identity with other class A β-lactamases and harbors two cysteine residues conserved in all class A carbapenemases. FTU-1 is the first weak class A carbapenemase that is native to Francisella tularensis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.