ArticleSurgical endoscopy2012
Sympathetic chain clipping for hyperhidrosis is not a reversible procedure.
Article in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Long-term results of endoscopic sympathetic block using the Lin-Telaranta classification.Surgical endoscopy · 2013Trial
- The history and development of sympathetic trunk reconstruction: a 40-year journey from open surgery to robotic-assisted microsurgery.Journal of robotic surgery · 2025Review
- Is RATS Superior to VATS in Thoracic Autonomic Nervous System Surgery?Journal of clinical medicine · 2024Review
- Robotic sympathetic trunk reconstruction for compensatory sweating after thoracic sympathectomy.JTCVS techniques · 2023Article
- Surgical management of compensatory sweating: A systematic review.Frontiers in surgery · 2023Review
- Effects of thoracic sympathetic stimulation on palmar perfusion: a preliminary study in pigs.General thoracic and cardiovascular surgery · 2022Article
- Minimally Invasive Sympathicotomy for Palmar Hyperhidrosis and Facial Blushing: Current Status and the Hyperhidrosis Expert Center Approach.Journal of clinical medicine · 2022Review
- How to Prevent, Reduce, and Treat Severe Post Sympathetic Chain Compensatory Hyperhidrosis: 2021 State of the Art.Frontiers in surgery · 2021Review
- Electrophysiological evaluation of efficacy of clipping in thoracic sympathectomy: An experimental cadaveric study.Turk gogus kalp damar cerrahisi dergisi · 2020Article
- Does clip removal help for compensatory hyperhidrosis complicating thoracic sympathetic clipping?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Can we predict the compensatory hyperhidrosis following a thoracic sympathectomy?Indian journal of thoracic and cardiovascular surgery · 2019Article
- Effectiveness, success rates, and complications of different thoracoscopic sympathectomy techniques in patients with palmar hyperhidrosis.Turk gogus kalp damar cerrahisi dergisi · 2018Article
- Pulsed radiofrequency stimulation suppresses palmar hyperhidrosis in an animal study.Brain and behavior · 2017Article
- Comparisons of the clinical outcomes of thoracoscopic sympathetic surgery for palmar hyperhidrosis: R4 sympathicotomy versus R4 sympathetic clipping versus R3 sympathetic clipping.Journal of thoracic disease · 2016Article
- Is clipping the preferable technique to perform sympathicotomy? A retrospective study and review of the literature.Langenbeck's archives of surgery · 2015Review
- Sympathetic chain clipping for hyperhidrosis is not a reversible procedure.Surgical endoscopy · 2013Article
- In the search for the treatment of compensatory sweating.TheScientificWorldJournal · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany techniques have been used to treat palmar hyperhidrosis. Compensatory sweating is a difficult adverse effect. Clipping has been proposed because of its supposed reversibility when clips are removed at a later date. The primary aims of this article are to investigate the neuronal lesion of the sympathetic chain caused by clipping and to study the possibility of regeneration after removal of the clips.
methodsWe performed an experimental study at the Minimally Invasive Surgery Centre Jesus Uson in Caceres (Spain). We used a swine model, performing clipping, unclipping, and extirpation of different segments of sympathetic chain with clips and after clip removal, following a chronogram of 10, 20, and 30 days. Pathologic studies of specimens and statistics were done at the University of Seville.
resultsTen days after clipping, all sympathetic chains displayed evident Wallerian degeneration. Twenty days after clipping, Wallerian degeneration of myelinated fibers was more widespread and also more striking. Thirty days after clipping, a very marked macrophagic reaction was visible, with multiple signs of phagocytosis of myelin debris. By 30 days post operation and 20 days after clip removal, a few residual myelin and amyelinated fibers were visible. These findings suggest that axon regeneration is not possible.
conclusionsThere are Wallerian degeneration and axon loss 10 days after clipping. The almost total absence of myelinated and amyelinated fibers following clip removal suggests that there was no nerve regeneration, and that therefore clipping cannot be considered a reversible technique.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.