Evidence map›Paper›PMID 22082691›Full record

ReviewQuarterly reviews of biophysics2012

Electron tomography of cells.

Lu Gan, Grant J Jensen

Abstract readReview
In one paragraph

Review in Quarterly reviews of biophysics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
12.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 169 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Visualizing Cell Structures with Minecraft.Biophysicist (Rockville, Md.) · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Electron Tomography as a Tool to Study SARS-CoV-2 Morphology.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. Sample Preparation for In Situ Cryotomography of Mammalian Cells.Journal of visualized experiments : JoVE · 2023
    Article
  19. Review
  20. High-throughput cryo-ET structural pattern mining by unsupervised deep iterative subtomogram clustering.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lu GanDivision of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Grant J Jensen
California Institute of Technology · USHoward Hughes Medical Institute · US

Funding

X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Structural biology of HIV buddingP01GM066521 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY IAN · 2002 to 2006
$6.6M
Structure and function of the prokaryotic cytoskeleton by electron cryotomographyR01GM094800 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI JENSEN, GRANT J · 2011 to 2015
$1.7M
NIGMS NIH HHS GM066521NIGMS NIH HHS GM094800NIGMS NIH HHS P01 GM066521NIGMS NIH HHS P50 GM082545NIGMS NIH HHS R01 GM094800
6 · The paper itself

Abstract

The electron microscope has contributed deep insights into biological structure since its invention nearly 80 years ago. Advances in instrumentation and methodology in recent decades have now enabled electron tomography to become the highest resolution three-dimensional (3D) imaging technique available for unique objects such as cells. Cells can be imaged either plastic-embedded or frozen-hydrated. Then the series of projection images are aligned and back-projected to generate a 3D reconstruction or 'tomogram'. Here, we review how electron tomography has begun to reveal the molecular organization of cells and how the existing and upcoming technologies promise even greater insights into structural cell biology.

Indexed as

AnimalsBacteriaCellsElectron Microscope TomographyHumansImage Processing, Computer-AssistedMacromolecular SubstancesVirus Physiological PhenomenaMacromolecular Substances

Identifiers

PMID22082691
PMCPMC12019784
OpenAlexW2169803474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.