ReviewJournal of endocrinological investigation2012
Relationship between testosterone deficiency and cardiovascular risk and mortality in adult men.
Review in Journal of endocrinological investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials.BMC medicine · 2013Pooled it
- Provocative stimulation of the hypothalamic-pituitary-testicular axis in men with spinal cord injury.Spinal cord · 2016Trial
- [Testosterone replacement therapy and its relationship with hyperestrogenism and obesity. Problems of laboratory diagnostics of hyperestrogenism].Problemy endokrinologii · 2021Article
- Advances in stem cell research for the treatment of primary hypogonadism.Nature reviews. Urology · 2021Review
- LPCN 1144 Resolves NAFLD in Hypogonadal Males.Hepatology communications · 2020Article
- Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study.British journal of cancer · 2017Article
- Investigation of testosterone-mediated non-transcriptional inhibition of CaBiomedical reports · 2016Article
- Testosterone Replacement Therapy on the Natural History of Prostate Disease.Current urology reports · 2015Review
- Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men.The aging male : the official journal of the International Society for the Study of the Aging Male · 2015Article
- Disease burden evaluation of fall-related events in the elderly due to hypoglycemia and other diabetic complications: a clinical review.Clinical epidemiology · 2014Review
- Seasonal variations of plasma gonadotropin, prolactin, and testosterone levels in primary and secondary hypogonadism: evidence for an independent testicular role.Journal of endocrinological investigation · 2013Article
- The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons.Atherosclerosis · 2012Article
- [Intermittent androgen deprivation as therapy for androgen-sensitive prostate cancer. Sense or nonsense?].Der Urologe. Ausg. A · 2012Review
- Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review.Current diabetes reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classic male hypogonadism is associated with known adverse effects including decreased libido, erectile dysfunction, osteoporosis, and changes in body composition. Recently, we have come to appreciate that reduction in serum testosterone (T) levels resulting from aging or chronic disease or androgen deprivation therapy (ADT) have consequences similar to those seen in classic male hypogonadism which include increased fat mass, decreased lean body mass, decreased muscle strength, and sexual dysfunction. These data suggest that low T levels may represent a newly recognized cardiometabolic risk factor. Therefore, we carried out a careful review of the literature, focusing on major turning points of research and studies which gave more important and controversial contribution to the cardiovascular role of T. Observational studies and clinical trials investigating the relationship between T levels and cardiovascular disease and mortality were identified byMedline search. The results were synthesized, tabulated, and interpreted. The aim of this review is to discuss the association between low T levels and adverse metabolic profile such as insulin resistance, metabolic syndrome, and diabetes. We will also investigate the potential mechanisms by which male hypogonadism, especially age related or induced by ADT, may increase cardio-metabolic risk. Finally we will detail the emerging relationship between low T and mortality in men addressing also the reverse hypothesis that low T has a protective role by turning off T-dependent functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.