ArticleBMC genomics2011
The MetJ regulon in gammaproteobacteria determined by comparative genomics methods.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cross-regulation of amino acid synthesis and anaerobic electron transfer by MetR-mediated methionine signaling.Journal of bacteriology · 2026Article
- Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization bymSphere · 2025Article
- Genome-wide identification of genes critical forVirulence · 2023Article
- Taxonomic and Functional Shifts in the Sprout Spent Irrigation Water Microbiome in Response toApplied and environmental microbiology · 2021Article
- Proteomics of intracellular Salmonella enterica reveals roles of Salmonella pathogenicity island 2 in metabolism and antioxidant defense.PLoS pathogens · 2019Article
- Methionine biosynthesis and transport are functionally redundant for the growth and virulence ofThe Journal of biological chemistry · 2018Article
- Elucidation of the bacterial communities associated with the harmful microalgae Alexandrium tamarense and Cochlodinium polykrikoides using nanopore sequencing.Scientific reports · 2018Article
- The Trichodesmium consortium: conserved heterotrophic co-occurrence and genomic signatures of potential interactions.The ISME journal · 2017Article
- Insights on Osmotic Tolerance Mechanisms in Escherichia coli Gained from an rpoC Mutation.Bioengineering (Basel, Switzerland) · 2017Article
- Growth Characterization of Single and DoubleFrontiers in veterinary science · 2017Article
- Carbon Monoxide Gas Is Not Inert, but Global, in Its Consequences for Bacterial Gene Expression, Iron Acquisition, and Antibiotic Resistance.Antioxidants & redox signaling · 2016Article
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- Comparative genomics of transcriptional regulation of methionine metabolism in Proteobacteria.PloS one · 2014Article
- Article
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2 authors.
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Abstract
backgroundWhole-genome sequencing of bacteria has proceeded at an exponential pace but annotation validation has lagged behind. For instance, the MetJ regulon, which controls methionine biosynthesis and transport, has been studied almost exclusively in E. coli and Salmonella, but homologs of MetJ exist in a variety of other species. These include some that are pathogenic (e.g. Yersinia) and some that are important for environmental remediation (e.g. Shewanella) but many of which have not been extensively characterized in the literature.
resultsWe have determined the likely composition of the MetJ regulon in all species which have MetJ homologs using bioinformatics techniques. We show that the core genes known from E. coli are consistently regulated in other species, and we identify previously unknown members of the regulon. These include the cobalamin transporter, btuB; all the genes involved in the methionine salvage pathway; as well as several enzymes and transporters of unknown specificity.
conclusionsThe MetJ regulon is present and functional in five orders of gammaproteobacteria: Enterobacteriales, Pasteurellales, Vibrionales, Aeromonadales and Alteromonadales. New regulatory activity for MetJ was identified in the genomic data and verified experimentally. This strategy should be applicable for the elucidation of regulatory pathways in other systems by using the extensive sequencing data currently being generated.
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