ArticleInfectious agents and cancer2011
Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.
Article in Infectious agents and cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Racial Disparities Associated with the Prevalence of Vaccine and Non-Vaccine HPV Types and Multiple HPV Infections between Asia and Africa: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Effect of HIV Infection on Human Papillomavirus Types Causing Invasive Cervical Cancer in Africa.Journal of acquired immune deficiency syndromes (1999) · 2016Pooled it
- Pooled it
- Genotypes of human papillomavirus and clinical pathological features among patients with anal carcinoma in North-western Tanzania.Infectious agents and cancer · 2026Article
- Looking Back, Moving Forward: Challenges and Opportunities for Global Cervical Cancer Prevention and Control.Viruses · 2024Review
- High-risk HPV genotypes in Zimbabwean women with cervical cancer: Comparative analyses between HIV-negative and HIV-positive women.PloS one · 2021Article
- Article
- Prevalence of Specific Types of Human Papiloma Virus in Cervical Intraepithelial Lesions and Cervical Cancer in Macedonian Women.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- HPV genotype distribution in Brazilian women with and without cervical lesions: correlation to cytological data.Virology journal · 2016Article
- Human papillomavirus related cervical cancer and anticipated vaccination challenges in Ethiopia.International journal of health sciences · 2016Review
- Article
- Distribution of HPV genotypes in Shanghai women.International journal of clinical and experimental pathology · 2015Article
- IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.Infectious agents and cancer · 2015Article
- HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA.Cancer causes & control : CCC · 2014Article
- PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
- The burden of human papillomavirus infections and related diseases in sub-saharan Africa.Vaccine · 2013Review
- Article
- Article
- Spectrum of high risk human papillomavirus types in women in Kaduna State, Nigeria.Annals of African medicineArticle
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundInfection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer; however, these genotypes remain poorly characterized in many African countries. To contribute to the characterization of HPV genotypes in Northeastern Tanzania, we recruited 215 women from the Reproductive Health Clinic at Kilimanjaro Christian Medical Centre. Cervical scrapes and biopsies were obtained for cytology and HPV DNA detection.
results79 out of 215 (36.7%) enrolled participants tested positive for HPV DNA, with a large proportion being multiple infections (74%). The prevalence of HPV infection increased with lesion grade (14% in controls, 67% in CIN1 cases and 88% in CIN2-3). Among ICC cases, 89% had detectable HPV. Overall, 31 HPV genotypes were detected; the three most common HPV genotypes among ICC were HPV16, 35 and 45. In addition to these genotypes, co-infection with HPV18, 31, 33, 52, 58, 68 and 82 was found in 91% of ICC. Among women with CIN2-3, HPV53, 58 and 84/83 were the most common. HPV35, 45, 53/58/59 were the most common among CIN1 cases.
conclusionsIn women with no evidence of cytological abnormalities, the most prevalent genotypes were HPV58 with HPV16, 35, 52, 66 and 73 occurring equally. Although numerical constraints limit inference, findings that 91% of ICC harbor only a small number of HPV genotypes suggests that prevention efforts including vaccine development or adjuvant screening should focus on these genotypes.
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Registered trials
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