ArticleCurrent opinion in solid state & materials science2011
Polymer physics of the cytoskeleton.
Article in Current opinion in solid state & materials science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- When the Cytoskeleton Fails: Primary Structural Defects Underlying Disorders with Neurological Involvement.International journal of molecular sciences · 2026Review
- Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment.Journal of cellular physiology · 2026Review
- Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics.npj biomedical innovations · 2026Review
- Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025.Osteoarthritis and cartilage open · 2026Article
- Crosslinker identity and dynamics regulate F-actin network structure and mechanics.Frontiers in cell and developmental biology · 2026Article
- The PI3K-AKT-mTOR signaling pathway mediates epithelial mesenchymal transition and cytoskeletal architecture changes induce to renal fibrosis after Bisphenol S exposure.Scientific reports · 2025Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway.Discover oncology · 2025Article
- Intermediate filaments and their associated molecules.Journal of biomedical research · 2025Article
- Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin.Soft matter · 2025Article
- Rheology in the Biological Sciences.Rheology bulletin · 2024Article
- A Simulation of the Mechanical Testing of the Cell Membrane and Cytoskeleton.Micromachines · 2024Article
- Article
- Kinesin and myosin motors compete to drive rich multiphase dynamics in programmable cytoskeletal composites.PNAS nexus · 2023Article
- Review
- Measuring the linear viscoelastic regime of MCF-7 cells with a monolayer rheometer in the presence of microtubule-active anti-cancer drugs at high concentrations.Interface focus · 2022Article
- Nonlinear Microscale Mechanics of Actin Networks Governed by Coupling of Filament Crosslinking and Stabilization.Polymers · 2022Article
- Single-chain models illustrate the 3D RNA folding shape during translation.Biophysical reports · 2022Article
- Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics.Journal of visualized experiments : JoVE · 2022Article
- Dynamic stiffening of the flagellar hook.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The cytoskeleton is generally visualized by light or electron microscopy as a meshwork of protein filaments that spans the space between the nuclear envelope and the plasma membrane. In most cell types, this meshwork is formed by a three dimensional composite network of actin filaments, microtubules (MT), and intermediate filaments (IF) together with the host of proteins that bind to the sides or ends of these linear polymers. Cytoskeletal binding proteins regulate filament length, crosslink filaments to each other, and apply forces to the filaments. One approach to modeling the mechanical properties of the cytoskeleton and of cell in general is to consider the elements of the cytoskeleton as polymers, using experimental methods and theoretical models developed for traditional polymers but modified for the much larger, stiffer, and fragile biopolymers comprising the cytoskeleton. The presence of motor proteins that move actin filaments and microtubules also creates a new class of active materials that are out of thermodynamic equilibrium, and unconstrained by limitations of the fluctuation-dissipation theorem. These active materials create rich opportunities for experimental design and theoretical developments. The degree to which the mechanics of live cells can usefully be modeled as highly complex polymer networks is by no means certain, and this article will discuss recent progress in quantitatively measuring cytoskeletal polymer systems and relating them to the properties of the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.