Evidence map›Paper›PMID 22081748›Full record

ArticleCurrent topics in biochemical research2010

PTEN-Associated Complexes: An Overview.

Sherly Mosessian, Hong Wu

Abstract read
In one paragraph

Article in Current topics in biochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sherly MosessianDepartment of Molecular and Medical Pharmacology, UCLA.
Hong Wu

Funding

Study of cell-of-origin and cancer stem cells in prostatic adenocarcinomaR01CA121110 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, HONG · 2008 to 2012
$1.7M
PTEN and Prostate Cancer ProgressionR01CA107166 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, HONG · 2004 to 2008
$1.7M
NCI NIH HHS R01 CA107166NCI NIH HHS R01 CA121110
6 · The paper itself

Abstract

PTEN is a tumor suppressor best characterized for its role as a lipid phosphatase in antagonizing the PI3-kinase pathway. Several recent studies have identified proteins that form high molecular weight complexes with PTEN in different subcellular compartments. PTEN is critical for early embryonic development, cell proliferation, cell survival and stem cell function. The discovery of PTEN complex components may help our understanding of its biological functions. In this review, PTEN complex components, functions and their regulation will be discussed.

Identifiers

PMID22081748
PMCPMC3212753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.