ArticleAJNR. American journal of neuroradiology2012
Different patterns of fornix damage in idiopathic normal pressure hydrocephalus and Alzheimer disease.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Structural neuroimaging markers of normal pressure hydrocephalus versus Alzheimer's dementia and Parkinson's disease, and hydrocephalus versus atrophy in chronic TBI-a narrative review.Frontiers in neurology · 2024Review
- Relationship between disproportionately enlarged subarachnoid-space hydrocephalus and white matter tract integrity in normal pressure hydrocephalus.Scientific reports · 2023Article
- The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.The neuroradiology journal · 2021Review
- Dynamic functional networks in idiopathic normal pressure hydrocephalus: Alterations and reversibility by CSF tap test.Human brain mapping · 2021Article
- Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus: A Tensor Imaging Study.Scientific reports · 2020Article
- Article
- DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review.Neurosurgical review · 2015Review
- Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Fornix as an imaging marker for episodic memory deficits in healthy aging and in various neurological disorders.Frontiers in aging neuroscience · 2014Review
- A review of β-amyloid neuroimaging in Alzheimer's disease.Frontiers in neuroscience · 2014Review
- Neuroimaging in normal pressure hydrocephalus.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe fornix contains efferent fibers of the hippocampus and is in close contact with the corpus callosum. Part of the fornix is directly attached to the corpus callosum, and another part is suspended from the corpus callosum via the septum pellucidum. DTI can be used to evaluate the morphology and microstructural integrity of the fornix. We examined the pattern of fornix damage in patients with iNPH or AD. MATERIALS AND
methodsWe enrolled 22 patients with iNPH, 20 with AD, and 20 healthy controls. DTI data were obtained. The morphology (volume, length, and mean cross-sectional area) and FA values of the fornix were evaluated by using tract-specific analysis and compared among groups.
resultsThe volume, cross-sectional area, and FA value of the fornix were significantly smaller in patients with iNPH than in controls, whereas the length was significantly greater. In patients with AD, the volume, mean cross-sectional area, and FA value of the fornix were significantly smaller than those in controls, whereas the length was not altered. The fornix was significantly longer in patients with iNPH than in patients with AD, whereas the volume and cross-sectional areas were significantly smaller.
conclusionsOur results suggest that the different pathogeneses of these diseases lead to fornix damage through different mechanisms: through mechanical stretching due to lateral ventricular enlargement and corpus callosum deformation in patients with iNPH, and through degeneration secondary to hippocampal atrophy in patients with AD.
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