ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
Lentivirus-delivered Krüppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer.Journal of cellular and molecular medicine · 2019Article
- Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer.Pathology oncology research : POR · 2019Article
- Krüppel-like factor 8 induces epithelial-to-mesenchymal transition and promotes invasion of pancreatic cancer cells through transcriptional activation of four and a half LIM-only protein 2.Oncology letters · 2017Article
- Role of Krüppel-like factors in cancer stem cells.Journal of physiology and biochemistry · 2015Review
- Krüppel-like factor 8 contributes to hypoxia-induced MDR in gastric cancer cells.Cancer science · 2014Article
- Therapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer.BMC cancer · 2014Article
- Article
- Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2014Article
- Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.Molecular and cellular biology · 2013Article
- Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer.World journal of gastroenterology · 2013Article
- Downregulation of KLF8 expression by shRNA induces inhibition of cell proliferation in CAL27 human oral cancer cells.Medicina oral, patologia oral y cirugia bucal · 2013Article
- KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells.Journal of cancer research and clinical oncology · 2013Article
- Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a.American journal of cancer research · 2013Article
- A novel role of Krüppel-like factor 8 in DNA repair in breast cancer cells.The Journal of biological chemistry · 2012Article
- MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Krüppel-like factor 8 emerges as an important regulator of cancer.American journal of translational research · 2012Article
- Circulating Tumor Cells Expressing Krüppel-Like Factor 8 and Vimentin as Predictors of Poor Prognosis in Pancreatic Cancer Patients.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We found that the transcription factor Krüppel-like factor 8 (KLF8) was highly expressed in gastric cancer tissues and cell lines compared with adjacent noncancerous regions and gastric epithelial mucosa cells. We employed a lentivirus-mediated RNAi technique to knockdown KLF8 expression in gastric cancer cell line SGC7901 and observed its effects on cell growth in vitro and in vivo. Knockdown of KLF8 inhibited SGC7901 cell proliferation, promoted cell apoptosis, inhibited the tumorigenicity of SGC7901 cells, and significantly decreased tumor growth when the cells were injected into nude mice. These results indicated that overexpression of KLF8 may influence the biological behavior of SGC7901 gastric cancer cells. Knockdown of KLF8 expression by lentivirus-delivered siRNA may be useful as a therapeutic agent for the treatment of gastric cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.