ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Oral epithelial dysplasia and aphthous ulceration in a patient with ulcerative colitis: a case report.BMC oral health · 2023Article
- Study of Podoplanin Expression in Head and Neck Squamous Cell Carcinoma.Iranian journal of pathology · 2022Article
- Podoplanin in Inflammation and Cancer.International journal of molecular sciences · 2019Review
- Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma.Journal of clinical and experimental dentistry · 2017Article
- Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.Experimental and therapeutic medicine · 2017Article
- Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer.Clinical oral investigations · 2017Article
- Expression of Podoplanin in Laryngeal Squamous Cell Carcinoma and Dysplasia.Journal of clinical and diagnostic research : JCDR · 2017Article
- ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia.Oncology letters · 2017Article
- HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions.Oncology letters · 2016Article
- Pre-Cancerous Lesions in the Oral and Maxillofacial Region: A Literature Review with Special Focus on Etiopathogenesis.Iranian journal of pathology · 2016Review
- Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.Oncogene · 2015Article
- Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms.Oncotarget · 2015Article
- Podoplanin expressing cancer-associated fibroblasts in oral cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Article
- Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Intravascular papillary endothelial hyperplasia: diagnostic sequence and literature review of an orofacial lesion.Case reports in dentistry · 2014Article
- Ribosomal protein S6 phosphorylation is associated with epithelial dysplasia and squamous cell carcinoma of the oral cavity.Pathology oncology research : POR · 2013Article
- Cancer stem cell markers in head and neck squamous cell carcinoma.Stem cells international · 2013Article
- Assessment of podoplanin lymphatic vessel density in oral epithelial dysplasia.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human podoplanin, a type-1 transmembrane sialomucin-like glycoprotein, is involved in cell migration, tumor cell invasion, and metastasis. However, the role of the protein in squamous cell carcinoma (SCC) has been unclear and immunohistochemical reactivity for podoplanin differs from organ-to-organ. In the present study, immunohistochemical and molecular biological analyses were performed to examine the importance of podoplanin expression in oral precancerous and cancerous lesions and metastases. We immunohistochemically investigated the expression of podoplanin in 103 precancerous lesions, 69 primary oral squamous cell carcinomas (OSCCs), and 32 metastases, and that of E-cadherin and vimentin in primary OSCCs with metastasis. Furthermore, human OSCC-derived cell lines preincubated with fibrous growth factor-basic, epidermal growth factor (EGF), and tumor growth factor-β1 were subjected to real-time reverse transcription polymerase chain reaction. Immunoreactivity for podoplanin was detected in 89 (86.4%) of the precancerous lesions and the intensity was correlated with the degree of epithelial dysplasia (P = 0.016). Enhanced podoplanin expression was observed in 66 (95.7%) of the OSCCs and was significantly associated with a poor pathologic grade of differentiation (P = 0.020). Epithelial-mesenchymal transition was observed in 18 (58.1%) of the primary OSCCs with metastasis to regional lymph nodes. Messenger RNA for podoplanin was markedly increased after treatment with EGF in three OSCC cell lines. The present findings suggest that podoplanin is associated with tumor development via the oral dysplasia-carcinoma sequence and could be involved in a signaling pathway governing tumor growth and invasion in OSCC.
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