ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
A highly elastic and adhesive gelatin tissue sealant for gastrointestinal surgery and colon anastomosis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Hydrogel adhesives for upper gastrointestinal wound healing.Theranostics · 2026Review
- Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects.Science advances · 2025Article
- A tough bioadhesive hydrogel supports sutureless sealing of the dural membrane in porcine and ex vivo human tissue.Science translational medicine · 2024Article
- Double-layer adhesives for preventing anastomotic leakage and reducing post-surgical adhesion.Materials today. Bio · 2023Article
- Robust hydrogel adhesives for emergency rescue and gastric perforation repair.Bioactive materials · 2023Article
- An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation.Bioactive materials · 2022Article
- New Technologies to Prevent Anastomotic Leak.Clinics in colon and rectal surgery · 2021Review
- Improving the adhesion, flexibility, and hemostatic efficacy of a sprayable polymer blend surgical sealant by incorporating silica particles.Acta biomaterialia · 2019Article
- The use of a novel adhesive tissue patch as an aid to anastomotic healing.Annals of the Royal College of Surgeons of England · 2018Observational
- Engineering a highly elastic human protein-based sealant for surgical applications.Science translational medicine · 2017Article
- Elastic sealants for surgical applications.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2015Review
- Citrate-Based Biomaterials and Their Applications in Regenerative Engineering.Annual review of materials research · 2015Article
- A novel sutureless colonic anastomosis with self-gripping mesh: an experimental model.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe describe the development of a highly elastic and adhesive surgical tissue sealant, based on photochemically crosslinked gelatin, for sealing sutured incisions in the gastrointestinal (GI) tract in a rabbit surgical model and in a canine colon anastomosis study.
methodsThe study included in vitro assessment of mechanical parameters of the tissue sealant and in vivo analysis of burst strength and histology at 24 h, 3 days and 7 days post surgery, in a rabbit model, to assess progress of wound healing at the suture sites. Utility of this sealant to repair and seal a lower colonic resection and anastomosis procedure in a canine model was also investigated.
resultsWe show that a photopolymerised gelatin tissue sealant provides effective sealing of GI incisions and facilitates wound healing with no evidence of inflammation up to 28 days post-surgery. Blending of derivatised gelatin with underivatised gelatin allowed tuning of elasticity and elastic modulus of the photopolymerised sealant to suit surgical applications. High tissue adhesive strength was maintained at all blend ratios and exceeded 100 kPa.
conclusionsThis highly elastic and adhesive photopolymerised gelatin tissue sealant offers a number of advantages over currently available sealants suitable for GI surgical procedures.
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Registered trials
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