ArticleJournal of bioenergetics and biomembranes2011
Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines.
Article in Journal of bioenergetics and biomembranes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents.Pharmacological reports : PR · 2023Article
- Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated NaMolecules (Basel, Switzerland) · 2022Article
- Pharmacological Dissection of the Crosstalk between NaInternational journal of molecular sciences · 2022Article
- Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells.BioResearch open access · 2020Article
- Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel.Scientific reports · 2017Article
- EXPRESS: Voltage-dependent sodium (NaV) channels in group IV sensory afferents.Molecular pain · 2016Article
- Functional modulation of voltage-dependent sodium channel expression by wild type and mutated C121W-β1 subunit.Journal of bioenergetics and biomembranes · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-gated sodium channels are composed of one α subunit and one or more auxiliary β subunits. A standard reverse transcription-polymerase chain reaction assay was used to detect the mRNAs encoding for seven α subunits (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.9) and for the two non-covalently linked β1 and β3 auxiliary subunits in five different cell lines from rat, mouse and human origin. A semi-quantitavive RT-PCR analysis allowed to evaluate in each cell line, the relative expression level of each NaCh subunit previously detected. The expression profile of the cell lines was compared with that obtained from rat and mouse neural, skeletal muscle and cardiac tissues. This data provide a standard for the study of the modulation of the sodium channel expression in mammalian excitable tissues.
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