ArticleNature neuroscience2011
Inactivity-induced increase in nAChRs upregulates Shal K(+) channels to stabilize synaptic potentials.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular organization of central cholinergic synapses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Restoration of Shal/KCellular and molecular life sciences : CMLS · 2025Article
- ACh Transfers: Homeostatic Plasticity of Cholinergic Synapses.Cellular and molecular neurobiology · 2023Review
- Slo2/KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Differential gene expression in Drosophila melanogaster and D. nigrosparsa infected with the same Wolbachia strain.Scientific reports · 2021Article
- Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors inFrontiers in cellular neuroscience · 2021Review
- Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species.PloS one · 2021Article
- Cholinergic Synaptic Homeostasis Is Tuned by an NFAT-Mediated α7 nAChR-KCell reports · 2020Article
- Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- The mirtron miR-1010 functions in concert with its host gene SKIP to balance elevation of nAcRβ2.Scientific reports · 2020Article
- Article
- Control of Sleep Onset by Shal/KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cholinergic Homeostatic Synaptic Plasticity Drives the Progression of Aβ-Induced Changes in Neural Activity.Cell reports · 2018Article
- Article
- Developmental nicotine exposure alters potassium currents in hypoglossal motoneurons of neonatal rat.Journal of neurophysiology · 2017Article
- Linking aβ42-induced hyperexcitability to neurodegeneration, learning and motor deficits, and a shorter lifespan in an Alzheimer's model.PLoS genetics · 2015Article
- Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.Development (Cambridge, England) · 2014Article
- Article
- IA channels: diverse regulatory mechanisms.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Long-term synaptic changes, which are essential for learning and memory, are dependent on homeostatic mechanisms that stabilize neural activity. Homeostatic responses have also been implicated in pathological conditions, including nicotine addiction. Although multiple homeostatic pathways have been described, little is known about how compensatory responses are tuned to prevent them from overshooting their optimal range of activity. We found that prolonged inhibition of nicotinic acetylcholine receptors (nAChRs), the major excitatory receptors in the Drosophila CNS, resulted in a homeostatic increase in the Drosophila α7 (Dα7)-nAChR. This response then induced an increase in the transient A-type K(+) current carried by Shaker cognate L (Shal; also known as voltage-gated K(+) channel 4, Kv4) channels. Although increasing Dα7-nAChRs boosted miniature excitatory postsynaptic currents, the ensuing increase in Shal channels served to stabilize postsynaptic potentials. These data identify a previously unknown mechanism for fine tuning the homeostatic response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.