ArticleNature neuroscience2011
Cytokinesis remnants define first neuronal asymmetry in vivo.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Did axons evolve by activating cytokinesis during interphase? A hypothesis on the origin of neurons.Molecular biology of the cell · 2025Review
- Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133?Journal of nanobiotechnology · 2025Review
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.bioRxiv : the preprint server for biology · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.Frontiers in cell and developmental biology · 2024Article
- Centrosome-dependent microtubule modifications set the conditions for axon formation.Cell reports · 2022Article
- New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation.Molecular biology of the cell · 2022Review
- Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases.Frontiers in neuroscience · 2022Review
- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Establishing neuronal polarity: microtubule regulation during neurite initiation.Oxford open neuroscience · 2022Review
- Cytokinetic Abscission Regulation in Neural Stem Cells and Tissue Development.Current stem cell reports · 2021Article
- Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles.Communications biology · 2021Article
- Small noncoding vault RNA modulates synapse formation by amplifying MAPK signaling.The Journal of cell biology · 2021Article
- Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis.Frontiers in molecular neuroscience · 2021Article
- Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis inDevelopment (Cambridge, England) · 2020Article
- HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation.Frontiers in cell and developmental biology · 2020Article
- The postmitotic midbody: Regulating polarity, stemness, and proliferation.The Journal of cell biology · 2019Review
- The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation.Nature communications · 2019Article
- RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity.Cell reports · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polarization of a neuron begins with the appearance of the first neurite, thus defining the ultimate growth axis. Unlike late occurring polarity events (such as axonal growth), very little is known about this fundamental process. We show here that, in Drosophila melanogaster neurons in vivo, the first membrane deformation occurred 3.6 min after precursor division. Clustering of adhesion complex components (Bazooka (Par-3), cadherin-catenin) marked this place by 2.8 min after division; the upstream phosphatidylinositol 4,5-bisphosphate, by 0.7 min after division; and the furrow components RhoA and Aurora kinase, from the time of cytokinesis. Local DE-cadherin inactivation prevented sprout formation, whereas perturbation of division orientation did not alter polarization from the cytokinesis pole. This is, to our knowledge, the first molecular study of initial neuronal polarization in vivo. The mechanisms of polarization seem to be defined at the precursor stage.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.