A new cap for kinetochore fibre minus ends.

Sabine Petry, Ronald D Vale

Abstract readComment

In one paragraph

Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.EMBO reports · 2023
Article
BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms.Oncogene · 2023
Article
Nuclear transport factors: global regulation of mitosis.Current opinion in cell biology · 2015
Review
The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.Cell cycle (Georgetown, Tex.)
Review

4 · The record

Corrections and comments

Comment on
K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly.2011

5 · Who and what money

Authors and funding

2 authors.

Sabine PetryHoward Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.

Ronald D Vale

Funding

MICROTUBULE-BASED ORGANELLE TRANSPORTR01GM038499 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI VALE, RONALD D · 1988 to 2005

$1.2M

Role and Mechanism of Microtubule Nucleation within the Mitotic SpindleK99GM100013 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETRY, SABINE · 2012 to 2013

$180k

Howard Hughes Medical InstituteNIGMS NIH HHS K99 GM100013NIGMS NIH HHS R01 GM038499

6 · The paper itself

Abstract

In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.

Indexed as

AnimalsChromosome SegregationHumansKinetochoresNuclear Proteinsran GTP-Binding ProteinRNA-Binding ProteinsSpindle ApparatusMCRS1 protein, humanNuclear Proteinsran GTP-Binding ProteinRAN protein, humanRNA-Binding Proteins

Identifiers

PMID22081093

DOI10.1038/ncb2387

PMCPMC3532025

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.