ArticleNature structural & molecular biology2011
The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.
Article in Nature structural & molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Participation of miR165a in the Phytochrome Signal Transduction in Maize (International journal of molecular sciences · 2024Article
- TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.Nature communications · 2022Article
- Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery.Current opinion in structural biology · 2021Review
- piRNA- and siRNA-mediated transcriptional repression in Drosophila, mice, and yeast: new insights and biodiversity.EMBO reports · 2021Review
- Article
- TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.Nature communications · 2020Article
- RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.RNA biology · 2019Review
- Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast.Nucleic acids research · 2018Article
- Structural conservation of the PIN domain active site across all domains of life.Protein science : a publication of the Protein Society · 2017Review
- Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.Molecular biology of the cell · 2017Article
- Structure of the active form of human origin recognition complex and its ATPase motor module.eLife · 2017Article
- Review
- Review
- SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.Molecular cell · 2016Article
- Article
- The Chp1 chromodomain binds the H3K9me tail and the nucleosome core to assemble heterochromatin.Cell discovery · 2016Article
- Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.Scientific reports · 2015Article
- Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.Molecular and cellular biology · 2015Article
- The Mi-2 homolog Mit1 actively positions nucleosomes within heterochromatin to suppress transcription.Molecular and cellular biology · 2014Article
- DNA replication components as regulators of epigenetic inheritance--lesson from fission yeast centromere.Protein & cell · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
RNA interference (RNAi) is critical for the assembly of heterochromatin at Schizosaccharomyces pombe centromeres. Central to this process is the RNA-induced initiation of transcriptional gene silencing (RITS) complex, which physically anchors small noncoding RNAs to chromatin. RITS includes Ago1, the chromodomain protein Chp1, and Tas3, which forms a bridge between Chp1 and Ago1. Chp1 is a large protein with no recognizable domains, apart from its chromodomain. Here we describe how the structured C-terminal half of Chp1 binds the Tas3 N-terminal domain, revealing the tight association of Chp1 and Tas3. The structure also shows a PIN domain at the C-terminal tip of Chp1 that controls subtelomeric transcripts through a post-transcriptional mechanism. We suggest that the Chp1-Tas3 complex provides a solid and versatile platform to recruit both RNAi-dependent and RNAi-independent gene-silencing pathways for locus-specific regulation of heterochromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.