ArticleNature immunology2011
TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.
Article in Nature immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- The Ubiquitin Ligase Adaptor NDFIP1 Interacts with TRESK and Negatively Regulates the Background KInternational journal of molecular sciences · 2024Article
- The Function of Ubiquitination in T-Cell Development.Advances in experimental medicine and biology · 2024Review
- Mechanism study of ubiquitination in T cell development and autoimmune disease.Frontiers in immunology · 2024Review
- Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer.Frontiers in oncology · 2021Article
- Modulating Th2 Cell Immunity for the Treatment of Asthma.Frontiers in immunology · 2021Review
- CCL26 regulates the proportion of CD4Experimental and therapeutic medicine · 2020Article
- Itch regulation of innate and adaptive immune responses in mice and humans.Journal of leukocyte biology · 2020Review
- Regulation of autoimmune disease by the E3 ubiquitin ligase Itch.Cellular immunology · 2019Review
- Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.EMBO reports · 2018Article
- The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8Cell reports · 2018Article
- Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.Nature communications · 2017Article
- Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection.Cold Spring Harbor perspectives in biology · 2017Review
- IL-1β induced HIF-1α inhibits the differentiation of human FOXP3Scientific reports · 2017Article
- The transcription factor musculin promotes the unidirectional development of peripheral TNature immunology · 2017Article
- Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production.Scientific reports · 2017Article
- Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells.Frontiers in immunology · 2017Article
- Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.Nature immunology · 2016Article
- Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci.Clinical and translational gastroenterology · 2016Article
- Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible regulatory T cells (iT(reg) cells). In vitro, Ndfip1-deficient T cells expressed normal amounts of the transcription factor Foxp3 during the first 48 h of iT(reg) cell differentiation; however, this expression was not sustained. Abortive Foxp3 expression was caused by production of interleukin 4 (IL-4) by Ndfip1(-/-) cells. We found that Ndfip1 expression was transiently upregulated during iT(reg) cell differentiation in a manner dependent on transforming growth factor-β (TGF-β). Once expressed, Ndfip1 promoted degradation of the transcription factor JunB mediated by the E3 ubiquitin ligase Itch, thus preventing IL-4 production. On the basis of our data, we propose that TGF-β signaling induces Ndfip1 expression to silence IL-4 production, thus permitting iT(reg) cell differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.