ArticleDigestive diseases and sciences2012
Impact of Helicobacter pylori infection and microscopic duodenal histopathological changes on clinical symptoms of patients with functional dyspepsia.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015Guideline
- Risk Factors for Mucosal Redness in the Duodenal Bulb as Detected via Linked Color Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- From Primary Data to Ethnopharmacological Investigations onPlants (Basel, Switzerland) · 2024Article
- Differences in Duodenal Mast Cell and Eosinophil Counts Between Patients With Functional Dyspepsia and Healthy People.Middle East journal of digestive diseases · 2021Article
- Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia.Journal of neurogastroenterology and motility · 2021Review
- Article
- Degranulated Eosinophils Contain More Fine Nerve Fibers in the Duodenal Mucosa of Patients With Functional Dyspepsia.Journal of neurogastroenterology and motility · 2019Article
- Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches.Expert review of clinical immunology · 2018Review
- Time trend occurrence of duodenal intraepithelial lymphocytosis and celiac disease in an open access endoscopic population.United European gastroenterology journal · 2017Article
- Significance of duodenal mucosal lesions: can they be a clue to a systemic disease?The Korean journal of internal medicine · 2017Article
- Helicobacter pylori-Associated Upper Gastrointestinal Symptoms: FD or HpD?Digestive diseases and sciences · 2017Article
- Is duodenal biopsy appropriate in areas endemic forNorthern clinics of Istanbul · 2017Article
- Impact of microscopic duodenitis on symptomatic response to Helicobacter pylori eradication in functional dyspepsia.Digestive diseases and sciences · 2015Article
- An examination of the relationship between the endoscopic appearance of duodenitis and the histological findings in patients with epigastric pain.International journal of clinical and experimental pathology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the microscopic histopathological changes in duodenal tissue and its relationship to the severity of symptoms in patients with functional dyspepsia while taking the effect of Helicobacter pylori (H. pylori) infection into account.
methodsSeveral gastric and duodenal biopsy specimens were obtained in 217 patients with functional dyspepsia and were evaluated for H. pylori infection and histopathological changes. Severity of symptoms was assessed by Leeds Dyspepsia Questionnaire (LDQ) and its relationship to histopathological changes and H. pylori infection status was assessed.
resultsHelicobacter pylori infection was associated with presence and severity of microscopic duodenitis (p < 0.001). In H. pylori-infected patients, the presence of microscopic duodenitis was independent of microscopic gastritis (p = 0.74). Severity of dyspepsia symptoms was not higher in H. pylori-infected patients than non-infected patients (p = 0.15), but in the presence of H. pylori infection and microscopic gastritis, microscopic duodenitis significantly worsened the LDQ symptom severity score (p < 0.001). In multivariate analysis, the odds of experiencing severe symptoms in patients with severe microscopic duodenitis was 2.22 times greater than in individuals with very mild, mild, or moderate duodenitis.
conclusionsMicroscopic duodenitis in H. pylori-infected patients may play a major role in producing and aggravating symptoms in FD patients and may be a determinant factor to consider in whether to treat H. pylori infection in functional dyspepsia.
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