ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2012
The regulation of food intake in mammalian hibernators: a review.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 118 citations in OpenAlex.
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- The suprachiasmatic nucleus: a central pacemaker for temporal coordination of energy metabolic homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care.Canadian journal of zoology · 2026Article
- New Insight Into Male Infertility: Deviation From Basic Tenets of Life.Oxidative medicine and cellular longevity · 2026Review
- Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice.Science (New York, N.Y.) · 2025Article
- Seasonal fluctuations in BDNF regulate hibernation and torpor in golden-mantled ground squirrels.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Editorial: Torpor and hibernation: metabolic and physiological paradigms.Frontiers in physiology · 2024Article
- The fructose survival hypothesis for obesity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Food availability positively affects the survival and somatic maintenance of hibernating garden dormice (Eliomys quercinus).Frontiers in zoology · 2023Article
- Short Photoperiod-Dependent Enrichment ofInternational journal of molecular sciences · 2023Article
- Why hibernate? Predator avoidance in the edible dormouse.Mammal research · 2023Review
- Energy expenditure and body composition in a hibernator, the alpine marmot.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- The physiology of experimental overfeeding in animals.Molecular metabolism · 2022Review
- Dictyostelium discoideum cells retain nutrients when the cells are about to outgrow their food source.Journal of cell science · 2022Article
- Intra-seasonal variation in feeding rates and diel foraging behaviour in a seasonally fasting mammal, the humpback whale.Royal Society open science · 2022Article
- Morphometric parameters predict body fat proportions in common hamsters.Journal of mammalogy · 2022Article
- Analysis of body condition indices reveals different ecotypes of the Antillean manatee.Scientific reports · 2021Article
- Development of metabolic inflammation during pre-hibernation fattening in 13-lined ground squirrels (Ictidomys tridecemlineatus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Seasonal Regulation of Metabolism: The Effect of Wintertime Fasting and Autumnal Fattening on Key Central Regulators of Metabolism and the Metabolic Profile of the Raccoon Dog (International journal of molecular sciences · 2021Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most profound hallmarks of mammalian hibernation is the dramatic reduction in food intake during the winter months. Several species of hibernator completely cease food intake (aphagia) for nearly 7 months regardless of ambient temperature and in many cases, whether or not food is available to them. Food intake regulation has been studied in mammals that hibernate for over 50 years and still little is known about the physiological mechanisms that control this important behavior in hibernators. It is well known from lesion experiments in non-hibernators that the hypothalamus is the main brain region controlling food intake and therefore body mass. In hibernators, the regulation of food intake and body mass is presumably governed by a circannual rhythm since there is a clear seasonal rhythm to food intake: animals increase food intake in the summer and early autumn, food intake declines in autumn and actually ceases in winter in many species, and resumes again in spring as food becomes available in the environment. Changes in circulating hormones (e.g., leptin, insulin, and ghrelin), nutrients (glucose, and free fatty acids), and cellular enzymes such as AMP-activated protein kinase (AMPK) have been shown to determine the activity of neurons involved in the food intake pathway. Thus, it appears likely that the food intake pathway is controlled by a variety of inputs, but is also acted upon by upstream regulators that are presumably rhythmic in nature. Current research examining the molecular mechanisms and integration of environmental signals (e.g., temperature and light) with these molecular mechanisms will hopefully shed light on how animals can turn off food intake and survive without eating for months on end.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.