SynthesisEuropean journal of clinical pharmacology2012
Exposed or not exposed? Exploring exposure classification in studies using administrative data to investigate outcomes following medication use during pregnancy.
Synthesis in European journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Maternal Medication Use and Childhood Cancer in Offspring-Systematic Review and Considerations for Researchers.American journal of epidemiology · 2021Pooled it
- Pregnancy and Delivery Outcomes Following Benzodiazepine Exposure: A Systematic Review and Meta-analysis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Pooled it
- Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- Measuring the continuation of antidepressant exposure prior to, during, and after pregnancy: A scoping review protocol.PloS one · 2025Article
- Article
- Characterizing Fit-for-Purpose Real-World Data: An Assessment of a Mother-Infant Linkage in the Japan Medical Data Center Claims Database.Clinical epidemiology · 2024Article
- Associations between antidepressant use patterns during pregnancy and birth outcomes among periconception antidepressant users.Pharmacotherapy · 2023Article
- Longitudinal Methods for Modeling Exposures in Pharmacoepidemiologic Studies in Pregnancy.Epidemiologic reviews · 2022Review
- Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort.PloS one · 2022Article
- Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects.JAMA psychiatry · 2020Article
- Article
- Atypical antipsychotic use during pregnancy and birth defect risk: National Birth Defects Prevention Study, 1997-2011.Schizophrenia research · 2020Article
- Safe Expectations: Current State and Future Directions for Medication Safety in Pregnancy Research.Clinical therapeutics · 2019Article
- Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs.Neurology · 2019Article
- Adherence to and Persistence with Antidepressant Medication during Pregnancy: Does It Differ by the Class of Antidepressant Medication Prescribed?Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Article
- Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort study.British journal of clinical pharmacology · 2018Article
- Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study.BMC pregnancy and childbirth · 2018Article
- Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control.Pharmacoepidemiology and drug safety · 2018Review
- Validation of maternal recall of early pregnancy medication exposure using prospective diary data.Annals of epidemiology · 2017Article
- Complex patterns of concomitant medication use: A study among Norwegian women using paracetamol during pregnancy.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this systematic review was to examine and compare differences in the way medication exposures are classified in studies using linked administrative data to investigate outcomes following medication use during pregnancy. This was undertaken with a focus on studies investigating specific neonatal outcomes following prenatal exposure to selective serotonin reuptake inhibitors (SSRIs).
methodsWe searched Medline and Embase to identify studies that used linked administrative data to investigate specific neonatal outcomes (congenital malformations, birth weight, gestational age) following prenatal exposure to SSRIs.
resultsKey factors such as dose, duration and timing of exposure were inconsistently addressed in the studies identified. In addition, there was a great deal of variability in the way medication exposures were classified and how women who stop taking their medication before or during early pregnancy are handled in analyses. Furthermore, there are issues in assuming how and when women who receive a dispensing for a medication actually take it during pregnancy. This creates a great deal of uncertainty around medication exposure during pregnancy in studies using linked administrative data, potentially resulting in biased risk estimates.
conclusionsThere is a need for greater focus on determining the most effective and accurate way of using linked administrative data to investigate outcomes following medication use during pregnancy in an effort to minimise potential biases.
Indexed as
Identifiers
22080182What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.