ArticleBiochimica et biophysica acta2012
Current and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations.
Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Modeling the Device Behavior of Biological and Synthetic Nanopores with Reduced Models.Entropy (Basel, Switzerland) · 2020Article
- Modeling the human NaDrug design, development and therapy · 2017Article
- Article
- Interacting ions in biophysics: real is not ideal.Biophysical journal · 2013Review
- Ion correlations in nanofluidic channels: effects of ion size, valence, and concentration on voltage- and pressure-driven currents.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
A reduced model of a sodium channel is analyzed using Dynamic Monte Carlo simulations. These include the first simulations of ionic current under approximately physiological ionic conditions through a model sodium channel and an analysis of how mutations of the sodium channel's DEKA selectivity filter motif transform the channel from being Na(+) selective to being Ca(2+) selective. Even though the model of the pore, amino acids, and permeant ions is simplified, the model reproduces the fundamental properties of a sodium channel (e.g., 10 to 1 Na(+) over K(+) selectivity, Ca(2+) exclusion, and Ca(2+) selectivity after several point mutations). In this model pore, ions move through the pore one at a time by simple diffusion and Na(+) versus K(+) selectivity is due to both the larger K(+) not fitting well into the selectivity filter that contains amino acid terminal groups and K(+) moving more slowly (compared to Na(+)) when it is in the selectivity filter.
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