ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.International journal of molecular sciences · 2020Review
- Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing.Scientific reports · 2015Article
- Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.Trends in immunology · 2012Review
- Epigenetics and the adaptive immune response.Molecular aspects of medicineReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Ag receptor loci are regulated to promote allelic exclusion, but the mechanisms are not well understood. Assembly of a functional TCR β-chain gene triggers feedback inhibition of V(β)-to-DJ(β) recombination in double-positive (DP) thymocytes, which correlates with reduced V(β) chromatin accessibility and a locus conformational change that separates V(β) from DJ(β) gene segments. We previously generated a Tcrb allele that maintained V(β) accessibility but was still subject to feedback inhibition in DP thymocytes. We have now further analyzed the contributions of chromatin accessibility and locus conformation to feedback inhibition using two novel TCR alleles. We show that reduced V(β) accessibility and increased distance between V(β) and DJ(β) gene segments both enforce feedback inhibition in DP thymocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.