ArticleJournal of pharmacological and toxicological methods2012
A coupled experimental and computational approach to quantify deleterious hemodynamics, vascular alterations, and mechanisms of long-term morbidity in response to aortic coarctation.
Article in Journal of pharmacological and toxicological methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Pathophysiologic Consequences of Early Coarctation Stenting in a Longitudinal Porcine Model.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Severity and duration-dependent aortic stiffening in a rabbit coarctation model identifies constitutive material parameters as promising regional biomarkers for hypertension progression.Scientific reports · 2026Article
- A Novel Diastolic Doppler Index Less Affected by Aortic Arch Anomalies Co-existing with Coarctation.Pediatric cardiology · 2025Article
- Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model.Journal of cardiovascular translational research · 2025Article
- Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction.Biomechanics and modeling in mechanobiology · 2025Article
- Deforming Patient-Specific Models of Vascular Anatomies to Represent Stent Implantation via Extended Position Based Dynamics.Cardiovascular engineering and technology · 2024Article
- Virtual Shape-Editing of Patient-Specific Vascular Models Using Regularized Kelvinlets.IEEE transactions on bio-medical engineering · 2024Article
- Coarctation Duration and Severity Predict Risk of Hypertension Precursors in a Preclinical Model and Hypertensive Status Among Patients.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Coarctation duration and severity predict risk of hypertension precursors in a preclinical model and hypertensive status among patients.medRxiv : the preprint server for health sciences · 2024Article
- Consistency of the continuous flow pressure gradient despite aortic arch anomalies co-existing with coarctation.medRxiv : the preprint server for health sciences · 2023Article
- Aortic Remodeling Kinetics in Response to Coarctation-Induced Mechanical Perturbations.Biomedicines · 2023Article
- Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model.Scientific reports · 2023Article
- A workflow for viewing biomedical computational fluid dynamics results and corresponding data within virtual and augmented reality environments.Frontiers in medical technology · 2023Article
- Clinical, Experimental, and Computational Validation of a New Doppler-Based Index for Coarctation Severity Assessment.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Automated generation of 0D and 1D reduced-order models of patient-specific blood flow.International journal for numerical methods in biomedical engineering · 2022Article
- Personalized Pre- and Post-Operative Hemodynamic Assessment of Aortic Coarctation from 3D Rotational Angiography.Cardiovascular engineering and technology · 2022Article
- The effect of coarctation degrees on wall shear stress indices.Scientific reports · 2021Article
- Non-invasive Prediction of Peak Systolic Pressure Drop across Coarctation of Aorta using Computational Fluid Dynamics.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- Validation and Diagnostic Performance of a CFD-Based Non-invasive Method for the Diagnosis of Aortic Coarctation.Frontiers in neuroinformatics · 2020Article
- Multimodality cardiac computed tomography angiography and magnetic resonance with clinical-grade scanners provide robust assessment of cardiac morphology and function in rabbits.Journal of thoracic disease · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
introductionCoarctation of the aorta (CoA) is associated with morbidity despite treatment. Although mechanisms remain elusive, abnormal hemodynamics and vascular biomechanics are implicated. We present a novel approach that facilitates quantification of coarctation-induced mechanical alterations and their impact on vascular structure and function, without genetic or confounding factors.
methodsRabbits underwent thoracic CoA at 10weeks of age (~9 human years) to induce a 20mmHg blood pressure (BP) gradient using permanent or dissolvable suture thereby replicating untreated and corrected CoA. Computational fluid dynamics (CFD) was performed using imaging and BP data at 32weeks to quantify velocity, strain and wall shear stress (WSS) for comparison to vascular structure and function as revealed by histology and myograph results.
resultsSystolic and mean BP was elevated in CoA compared to corrected and control rabbits leading to vascular thickening, disorganization and endothelial dysfunction proximally and distally. Corrected rabbits had less severe medial thickening, endothelial dysfunction, and stiffening limited to the proximal region despite 12weeks of normal BP (~4 human years) after the suture dissolved. WSS was elevated distally for CoA rabbits, but reduced for corrected rabbits. DISCUSSION: These findings are consistent with alterations in humans. We are now poised to investigate mechanical contributions to mechanisms of morbidity in CoA using these methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.