ArticleJournal of neuroscience methods2012
Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen.
Article in Journal of neuroscience methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Heterogeneity, Measurement, and Clinical Implications of Oxygenation, Cell Signaling, and Redox Biology in Glioblastoma and Adult Diffuse Gliomas, with Context from Other Brain Tumors.Antioxidants (Basel, Switzerland) · 2026Review
- Enhancing MR vascular Fingerprinting with realistic microvascular geometries.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- OxyChip embedded with radio-opaque gold nanoparticles for anatomic registration and oximetry in tissues.Magnetic resonance in medicine · 2022Article
- Contemporary Mouse Models in Glioma Research.Cells · 2021Review
- First-In-Human Study in Cancer Patients Establishing the Feasibility of Oxygen Measurements in Tumors Using Electron Paramagnetic Resonance With the OxyChip.Frontiers in oncology · 2021Article
- Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer.Cancers · 2020Review
- Characterization of a clinically used charcoal suspension for in vivo EPR oximetry.Magma (New York, N.Y.) · 2019Article
- Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications.Magnetic resonance in medicine · 2018Article
- EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model.Cell biochemistry and biophysics · 2017Article
- The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism.Genes & diseases · 2017Review
- Using Stable Free Radicals to Obtain Unique and Clinically Useful Data In Vivo in Human Subjects.Radiation protection dosimetry · 2016Review
- MR Vascular Fingerprinting in Stroke and Brain Tumors Models.Scientific reports · 2016Article
- Article
- Imaging Modalities to Assess Oxygen Status in Glioblastoma.Frontiers in medicine · 2015Review
- The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities.Antioxidants & redox signaling · 2014Review
- The updated biology of hypoxia-inducible factor.The EMBO journal · 2012Review
- MicroRNA-93 acts as an "anti-inflammatory tumor suppressor" in glioblastoma.Neuro-oncology advancesArticle
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5 authors.
Funding
Abstract
Tumor hypoxia plays a vital role in therapeutic resistance. Consequently, measurements of tumor pO(2) could be used to optimize the outcome of oxygen-dependent therapies, such as, chemoradiation. However, the potential optimizations are restricted by the lack of methods to repeatedly and quantitatively assess tumor pO(2) during therapies, particularly in gliomas. We describe the procedures for repeated measurements of orthotopic glioma pO(2) by multi-site electron paramagnetic resonance (EPR) oximetry. This oximetry approach provides simultaneous measurements of pO(2) at more than one site in the glioma and contralateral cerebral tissue. The pO(2) of intracerebral 9L, C6, F98 and U251 tumors, as well as contralateral brain, were measured repeatedly for five consecutive days. The 9L glioma was well oxygenated with pO(2) of 27-36 mm Hg, while C6, F98 and U251 glioma were hypoxic with pO(2) of 7-12mm Hg. The potential of multi-site EPR oximetry to assess temporal changes in tissue pO(2) was investigated in rats breathing 100% O(2). A significant increase in F98 tumor and contralateral brain pO(2) was observed on day 1 and day 2, however, glioma oxygenation declined on subsequent days. In conclusion, EPR oximetry provides the capability to repeatedly assess temporal changes in orthotopic glioma pO(2). This information could be used to test and optimize the methods being developed to modulate tumor hypoxia. Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2).
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